<strike id="amuic"></strike>
  • <abbr id="amuic"><option id="amuic"></option></abbr>
    <strike id="amuic"></strike>
    

  • <cite id="amuic"><source id="amuic"></source></cite>

    <cite id="amuic"><source id="amuic"></source></cite>
    • <ul id="amuic"><table id="amuic"></table></ul>
    


    
    
    
        
        
    
    
    

    

    
    
    
    
    
        
        
    
    
        
    

    

    
    
    
    
    
        
        
    
    
    
    最近搜索：細胞培養 微生物學 分子生物 生物化學 
    

    

    
	
    首頁>>免疫學>>一抗>>磷酸化核因子2相關因子2(Ser40)重組兔單克隆抗體  
    

    

    
	
    
    	
    
        	
    磷酸化核因子2相關因子2(Ser40)重組兔單克隆抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
    • 
                        	
      產品貨號：
      
                            
      BN42099R
      
                        
      • 
                    	
    • 
                        	
      中文名稱：
      
                            
      磷酸化核因子2相關因子2(Ser40)重組兔單克隆抗體 
      
                        
      • 
                                            	
    • 
                        	
      英文名稱：
      
                            
      Rabbit anti-phospho-Nrf2 (Ser40) Monoclonal antibody 
      
                        
      • 
                                                                    	
    • 
                        	
      品牌：
      
                            
      Biorigin 
      
                        
      • 
                    
    
                
    
            
    
            
    
                    
    
                        
      
                            
    • 
                                
      貨號
      
                                
      產品規格
      
                                
      售價
      
                                
      備注
      
                            
      • 
                                                        
    • 
                                
      BN42099R-50ul
      
                                
      50ul
      
                                
      ￥2020.00
      
                                
      交叉反應：Human,Mouse,Rat   推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt
      
                            
      • 
                                                        
    • 
                                
      BN42099R-100ul
      
                                
      100ul
      
                                
      ￥3240.00
      
                                
      交叉反應：Human,Mouse,Rat   推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt
      
                            
      • 
                                                    
    
                    
    
              
    
            
    
            	
    
                	
    產品描述
    
                
    
                
    
                	
    英文名稱phospho-Nrf2 (Ser40)
    中文名稱磷酸化核因子2相關因子2(Ser40)重組兔單克隆抗體
    別    名Nrf2 (phospho S40); p-Nrf2 (phospho S40); Nuclear factor-E2 related factor2; HEBP1; NF E2 related factor 2; NFE2 related factor 2; NFE2L2; Nrf 2; Nuclear factor erythroid 2 related factor 2; Nuclear factor erythroid derived 2 like 2; NF2L2_HUMAN.  
    產品類型磷酸化抗體 
    研究領域免疫學  染色質和核信號  細胞凋亡  轉錄調節因子  激酶和磷酸酶  
    抗體來源Rabbit
    克隆類型Monoclonal
    克 隆 號7G4
    交叉反應Human, Mouse, Rat, 
    產品應用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量68kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human Nrf2 around the phosphorylation site of Ser40:DF(p-S)QR 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor which regulates the expression of many detoxification and antioxidant enzymes. Nrf2 can potentially play a significant role in adaptive responses to oxidative stress. Nrf2 belongs to the Cap N Collar (CNC-bZIP) subfamily of basic /leucine zipper (bZIP) transcription factors.

    Function:
    Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

    Subunit:
    Heterodimer. Forms a ternary complex with PGAM5 and KEAP1. May bind DNA with an unknown protein. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.

    Subcellular Location:
    Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.

    Tissue Specificity:
    Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

    Post-translational modifications:
    Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus (By similarity).

    Similarity:
    Belongs to the bZIP family. CNC subfamily.
    Contains 1 bZIP domain.

    SWISS:
    Q16236

    Gene ID:
    4780

    Database links:
    Entrez Gene: 4780 Human
    Omim: 600492 Human
    SwissProt: Q16236 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications