<strike id="amuic"></strike>
  • <abbr id="amuic"><option id="amuic"></option></abbr>
    <strike id="amuic"></strike>
    

  • <cite id="amuic"><source id="amuic"></source></cite>

    <cite id="amuic"><source id="amuic"></source></cite>
    • <ul id="amuic"><table id="amuic"></table></ul>
    


    
    
    
        
        
    
    
    

    

    
    
    
    
    
        
        
    
    
        
    

    

    
    
    
    
    
        
        
    
    
    
    最近搜索：細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué) 
    

    

    
	
    首頁(yè)>>免疫學(xué)>>一抗>>Bcl-2同源結(jié)構(gòu)域蛋白單克隆抗體  
    

    

    
	
    
    	
    
        	
    Bcl-2同源結(jié)構(gòu)域蛋白單克隆抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
    • 
                        	
      產(chǎn)品貨號(hào)：
      
                            
      BN42042M
      
                        
      • 
                    	
    • 
                        	
      中文名稱：
      
                            
      Bcl-2同源結(jié)構(gòu)域蛋白單克隆抗體 
      
                        
      • 
                                            	
    • 
                        	
      英文名稱：
      
                            
      Mouse anti-Beclin 1 Monoclonal antibody 
      
                        
      • 
                                                                    	
    • 
                        	
      品牌：
      
                            
      Biorigin 
      
                        
      • 
                    
    
                
    
            
    
            
    
                    
    
                        
      
                            
    • 
                                
      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價(jià)
      
                                
      備注
      
                            
      • 
                                                        
    • 
                                
      BN42042M-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF
      
                            
      • 
                                                        
    • 
                                
      BN42042M-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF
      
                            
      • 
                                                    
    
                    
    
              
    
            
    
            	
    
                	
    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱Beclin 1
    中文名稱自噬效應(yīng)蛋白Beclin 1單克隆抗體
    別    名Beclin-1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843; BECN1_HUMAN.  
    研究領(lǐng)域腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  細(xì)胞凋亡  
    抗體來(lái)源Mouse
    克隆類型Monoclonal
    克 隆 號(hào)7B12
    交叉反應(yīng)Human, Mouse, Rat, 
    產(chǎn)品應(yīng)用WB=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量50kDa
    細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Beclin 1: 
    亞    型IgG
    純化方法affinity purified by Protein G
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons.

    Function:
    Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

    Subunit:
    Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB. Interacts with DAPK1. Interacts with human cytomegalovirus/HHV-5 protein TRS1.

    Subcellular Location:
    Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells.

    Tissue Specificity:
    Ubiquitous.

    Post-translational modifications:
    Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy.
    Ubiquitinated. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes.

    Similarity:
    Belongs to the beclin family.

    SWISS:
    Q14457

    Gene ID:
    8678

    Database links:
    Entrez Gene: 8678 Human
    Entrez Gene: 56208 Mouse
    Entrez Gene: 114558 Rat
    Omim: 604378 Human
    SwissProt: Q14457 Human
    SwissProt: O88597 Mouse
    SwissProt: Q91XJ1 Rat
    Unigene: 716464 Human
    Unigene: 178947 Mouse
    Unigene: 2776 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    BECN1是一種分子質(zhì)量為60KDa的蛋白質(zhì), 它能與細(xì)胞凋亡抑制劑Bcl-2相互作用, 減少中樞神經(jīng)系統(tǒng)的凋亡，參與PI3K復(fù)合物的組成和自噬體的形成。主要表達(dá)在胞質(zhì)。抑癌基因beclin 1通過自噬作用來(lái)調(diào)節(jié)細(xì)胞生長(zhǎng)。