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    首頁>>免疫學>>一抗>>c-fos單克隆抗體  
    

    

    
	
    
    	
    
        	
    c-fos單克隆抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN42018M
      
                        
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      中文名稱：
      
                            
      c-fos單克隆抗體 
      
                        
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      英文名稱：
      
                            
      Mouse anti-c-fos Monoclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
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      BN42018M-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應：Human,Mouse,Rat   推薦應用：WB
      
                            
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      BN42018M-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse,Rat   推薦應用：WB
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱c-fos
    中文名稱c-fos單克隆抗體
    別    名Cellular oncogene fos; FBJ murine osteosarcoma viral v fos oncogene homolog antibody FBJ Osteosarcoma Virus; FOS; FOS protein; G0 G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; v fos FBJ murine osteosarcoma viral oncogene homolog; AP-1; p55; FOS_HUMAN; Proto-oncogene c-Fos; G0/G1 switch regulatory protein 7.  
    研究領域腫瘤  細胞生物  免疫學  神經生物學  信號轉導  轉錄調節因子  
    抗體來源Mouse
    克隆類型Monoclonal
    克 隆 號8A3
    交叉反應Human, Mouse, Rat, 
    產品應用WB=1:500-2000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量41kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原Recombinant human c-fos Protein: 
    亞    型IgG
    純化方法affinity purified by Protein G
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008].

    Function:
    Nuclear phosphoprotein which forms a tight butnon-covalently linked complex with the JUN/AP-1 transcriptionfactor. In the heterodimer, FOS and JUN/AP-1 basic regions eachseems to interact with symmetrical DNA half sites. On TGF-betaactivation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at theAP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Hasa critical function in regulating the Has a critical function inregulating the development of cells destined to form and maintainthe skeleton. It is thought to have an important role in signaltransduction, cell proliferation and differentiation.

    Subunit:
    Heterodimer; with JUN (By similarity). Interacts withMAFB. Component of the SMAD3/SMAD4/JUN/FOS complexrequired for syngernistic TGF-beta-mediated transcription at theAP1 promoter site. Interacts with SMAD3; the interaction is weakeven on TGF-beta activation. Interacts with MAFB. Interacts withDSIPI; this interaction inhibits the binding of active AP1 to itstarget DNA.

    Subcellular Location:
    Nucleus.

    Post-translational modifications:
    Phosphorylated in the C-terminal upon stimulation by nervegrowth factor (NGF) and epidermal growth factor (EGF).Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on bothSer-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to proteinstabilization with phosphorylation on Ser-374 being the major sitefor protein stabilization on NGF stimulation. Phosphorylation onSer-362 and Ser-374 primes further phosphorylations on Thr-325 andThr-331 through promoting docking of MAPK to the DEF domain.Phosphorylation on Thr-232, induced by HA-RAS, activates thetranscriptional activity and antagonizes sumoylation.Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes toosteoblast transformation (By similarity). [PTM] Constitutively sumoylated by SUMO1, SUMO2 and SUMO3.Desumoylated by SENP2. Sumoylation requires heterodimerization withJUN and is enhanced by mitogen stimulation. Sumoylation inhibitsthe AP-1 transcriptional activity and is, itself, inhibited byRas-activated phosphorylation on Thr-232.

    Similarity:
    Belongs to the bZIP family. Fos subfamily.
    Contains 1 bZIP domain.

    SWISS:
    P01100

    Gene ID:
    2353

    Database links:
    Entrez Gene: 2353 Human
    Entrez Gene: 14281 Mouse
    Entrez Gene: 314322 Rat
    Omim: 164810 Human
    SwissProt: P01100 Human
    SwissProt: P01101 Mouse
    SwissProt: P12841 Rat
    Unigene: 246513 Mouse
    Unigene: 103750 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    c-fos的作用主要用于各種類型的惡性腫瘤如食管癌、鼻咽癌、乳腺癌、結腸癌以及腦病的研究。
    c-fos原癌基因及其蛋白產物不僅參與細胞的正常生長、分化過程，而且也參與細胞內信息傳遞過程和細胞的能量代謝過程，對細胞的增生、分化、轉化都有調節作用、在生命活動中起著極為基礎而重要的作用。