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骨形態(tài)發(fā)生蛋白2抗體

產(chǎn)品貨號(hào)：

BN41972M
中文名稱：

骨形態(tài)發(fā)生蛋白2抗體
英文名稱：

Mouse anti-BMP2 Monoclonal antibody
品牌：

Biorigin

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產(chǎn)品規(guī)格

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BN41972M-50ul

50ul

￥1486.00

交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB,ELISA
BN41972M-100ul

100ul

￥2360.00

交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB,ELISA
BN41972M-200ul

200ul

￥3490.00

交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱	BMP2
中文名稱	骨形態(tài)發(fā)生蛋白2抗體
別名	Bone morphogenetic protein 2; BMP 2; BMP 2A; BMP2A; BMP-2; BMP2_HUMAN.
研究領(lǐng)域	細(xì)胞生物免疫學(xué) 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 生長(zhǎng)因子和激素
抗體來(lái)源	Mouse
克隆類型	Monoclonal
克隆號(hào)	7F9
交叉反應(yīng)	Human,
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	13/44kDa
細(xì)胞定位	分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human BMP2 :
亞型	IgG
純化方法	affinity purified by Protein A
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis. Function: Induces cartilage and bone formation. Subunit: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN. Subcellular Location: Secreted. Tissue Specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine. Similarity: Belongs to the TGF-beta family. SWISS: P12643 Gene ID: 650 Database links: Entrez Gene: 650 Human Entrez Gene: 12156 Mouse Entrez Gene: 29373 Rat Omim: 112261 Human SwissProt: P12643 Human SwissProt: P21274 Mouse SwissProt: P49001 Rat Unigene: 73853 Human Unigene: 103205 Mouse Unigene: 90931 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)干細(xì)胞標(biāo)志物 BMP-2主要對(duì)未分化間充質(zhì)細(xì)胞和骨系細(xì)胞起到募集和分化作用。在骨形成早期，BMP-2不僅可使未分化間質(zhì)細(xì)胞向骨形成中心募集，并分化為骨系細(xì)胞，而且可使成纖維細(xì)胞、成肌細(xì)胞及骨髓的基細(xì)胞逆轉(zhuǎn)分化為骨系細(xì)胞。其主要過(guò)程是：增加或抑制這些細(xì)胞內(nèi)的某些特異性蛋白的分泌，使成纖維細(xì)胞分化為成骨細(xì)胞，成肌細(xì)胞快速分化為肥大的軟骨細(xì)胞，并促進(jìn)基質(zhì)鈣化。對(duì)于成骨細(xì)胞，BMP-2則可使之維持其特有細(xì)胞表型，并誘導(dǎo)成骨細(xì)胞標(biāo)志物的增高，促進(jìn)細(xì)胞外基質(zhì)鈣化。在骨形成后期，BMP-2還作為一種破骨細(xì)胞分化因子與其它支持破骨細(xì)胞分化因子直接或間接刺激破骨細(xì)胞分化，參與骨的重建。