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    首頁>>免疫學>>一抗>>過氧化物酶體增殖物激活受體γ輔激活子1α+β抗體  
    

    

    
	
    
    	
    
        	
    過氧化物酶體增殖物激活受體γ輔激活子1α+β抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41961R
      
                        
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      中文名稱：
      
                            
      過氧化物酶體增殖物激活受體γ輔激活子1α+β抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-PGC1 alpha + beta Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      備注
      
                            
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      BN41961R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應：Human,Rat,Pig(predicted:Mouse,Dog,Cow,Horse,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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      BN41961R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Rat,Pig(predicted:Mouse,Dog,Cow,Horse,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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      BN41961R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Rat,Pig(predicted:Mouse,Dog,Cow,Horse,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱PGC1 alpha + beta
    中文名稱過氧化物酶體增殖物激活受體γ輔激活子1α+β抗體
    別    名LEM6; Ligand effect modulator 6; PERC; Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; Peroxisome proliferative activated receptor, gamma, coactivator 1; Peroxisome proliferator activated receptor gamma coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC 1 (alpha); PGC 1 alpha; PGC 1v; PGC-1(beta); PGC-1-alpha; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC1; PGC1(alpha); PGC1A; PGC1v; PPAR gamma coactivator 1 alpha; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6; PPAR gamma coactivator 1; PPAR gamma coactivator variant form; PPAR gamma coactivator-1beta; PPAR-gamma coactivator 1-alpha; PPAR-gamma coactivator 1-beta; PPARGC 1 alpha; PPARGC-1-alpha; PPARGC-1-beta; PPARGC1; PPARGC1A; Ppargc1b; PRGC1_HUMAN; PRGC2_HUMAN.  






    研究領域心血管  細胞生物  染色質和核信號  信號轉導  糖尿病  表觀遺傳學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Rat, Pig,  (predicted: Mouse, Dog, Cow, Horse, Rabbit, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量88/113kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human PGC1 alpha + beta:151-250/798 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq].

    Function:
    Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis.

    Subunit:
    Binds MYBBP1A, which inhibits transcriptional activation by this protein. Interacts with PRDM16. Interacts with LRPPRC. Homooligomer. Interacts with LPIN1.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.

    Post-translational modifications:
    Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.

    Similarity:
    Contains 1 RRM (RNA recognition motif) domain.

    SWISS:
    Q9UBK2

    Gene ID:
    10891

    Database links:
    Entrez Gene: 10891 Human
    Entrez Gene: 133522 Human
    Entrez Gene: 170826 Mouse
    Entrez Gene: 19017 Mouse
    Entrez Gene: 291567 Rat
    Entrez Gene: 83516 Rat
    Omim: 604517 Human
    Omim: 608886 Human
    SwissProt: Q86YN6 Human
    SwissProt: Q9UBK2 Human
    SwissProt: 415302 Mouse
    SwissProt: O70343 Mouse
    SwissProt: Q8VHJ7 Mouse
    SwissProt: Q811R2 Rat
    SwissProt: Q9QYK2 Rat
    Unigene: 483816 Human
    Unigene: 527078 Human
    Unigene: 163382 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.