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最近搜索：細胞培養微生物學分子生物生物化學

首頁>>免疫學>>一抗>>FK506結合蛋白38抗體

FK506結合蛋白38抗體

產品貨號：

BN41960R
中文名稱：

FK506結合蛋白38抗體
英文名稱：

Rabbit anti-FKBP38 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41960R-50ul

50ul

￥1486.00

交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41960R-100ul

100ul

￥2360.00

交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41960R-200ul

200ul

￥3490.00

交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	FKBP38
中文名稱	FK506結合蛋白38抗體
別名	38 kDa FK 506 binding protein homolog; 38 kDa FK506-binding protein; 38 kDa FKBP; 38kDa antibody FK506 binding protein 8; FK506 binding protein 8, 38kDa; FK506 binding protein, 38kDa; FK506-binding protein 8; FKBP 38; FKBP-38; FKBP-8; FKBP8; FKBP8_HUMAN; FKBPR38; hFKBP38; Peptidyl-prolyl cis-trans isomerase FKBP8; PPIase FKBP8; Rotamase; Sam11.
研究領域	細胞生物免疫學信號轉導細胞凋亡轉錄調節因子結合蛋白
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, Rat, (predicted: Human, Chicken, Dog, Cow, Horse, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	46kDa
細胞定位	細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human FKBP38:255-350/412
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation. Tissue specificity: Widely expressed. Highest levels seen in the brain. Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Subunit: Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation. Subcellular Location: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Tissue Specificity: Widely expressed. Highest levels seen in the brain. Similarity: Contains 1 PPIase FKBP-type domain. Contains 3 TPR repeats. SWISS: Q14318 Gene ID: 23770 Database links: Entrez Gene: 23770 Human Entrez Gene: 14232 Mouse Entrez Gene: 290652 Rat Omim: 604840 Human SwissProt: Q14318 Human SwissProt: O35465 Mouse SwissProt: Q3B7U9 Rat Unigene: 173464 Human Unigene: 141864 Mouse Unigene: 99789 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.