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最近搜索：細胞培養微生物學分子生物生物化學

首頁>>免疫學>>一抗>>T淋巴細胞轉錄調節因子TFEB抗體

T淋巴細胞轉錄調節因子TFEB抗體

產品貨號：

BN41921R
中文名稱：

T淋巴細胞轉錄調節因子TFEB抗體
英文名稱：

Rabbit anti-TFEB Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41921R-50ul

50ul

￥1486.00

交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41921R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41921R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	TFEB
中文名稱	T淋巴細胞轉錄調節因子TFEB抗體
別名	Alpha TFEB; AlphaTFEB; bHLHe35; T cell transcription factor EB; T-cell transcription factor EB; TCFEB; Transcription factor EB; TFEB_HUMAN.

研究領域	細胞生物免疫學轉錄調節因子 t-淋巴細胞
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Rabbit, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	52kDa
細胞定位	細胞核細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TFEB:201-300/476
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Transcription factors of the basic helix-loop-helix zipper (bHLH-ZIP) family contain a basic domain, used for DNA binding, and HLH and ZIP domains, both used for oligomerization. TFEB was isolated from a human B-cell cDNA library using a binding sequence from the adenovirus major late promoter. This transcription factor probably binds to the USF/MLTF site and probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer. Function: Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Subunit: Homodimer and heterodimer; with TFE3 or MITF. Subcellular Location: Cytoplasm. Nucleus. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus. Post-translational modifications: Sumoylated; does not affect dimerization with MITF. Similarity: Belongs to the MiT/TFE family. Contains 1 basic helix-loop-helix (bHLH) domain. SWISS: P19484 Gene ID: 7942 Database links: Entrez Gene: 7942 Human Entrez Gene: 510032 Cow Entrez Gene: 609046 Dog Entrez Gene: 21425 Mouse Entrez Gene: 100157940 Pig Entrez Gene: 316214 Rat Omim: 600744 Human SwissProt: P19484 Human SwissProt: Q9R210 Mouse Unigene: 485360 Human Unigene: 715310 Human Unigene: 2305 Mouse Unigene: 22098 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.