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    首頁>>免疫學>>一抗>>生長分化因子9抗體  
    

    

    
	
    
    	
    
        	
    生長分化因子9抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41911R
      
                        
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      中文名稱：
      
                            
      生長分化因子9抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-GDF9 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN41911R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep)   推薦應用：WB,IHC-P,Flow-Cyt,ELISA
      
                            
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      BN41911R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep)   推薦應用：WB,IHC-P,Flow-Cyt,ELISA
      
                            
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      BN41911R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep)   推薦應用：WB,IHC-P,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱GDF9
    中文名稱生長分化因子9抗體
    別    名GDF9_HUMAN; GDF9; GDF-9; GDF 9; Growth differentiation factor 9.  
    研究領域心血管  免疫學  信號轉導  干細胞  生長因子和激素  細胞分化  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1ug/Test （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量15kDa
    細胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human GDF9:301-400/454 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹GDF 9 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell synthesized by ovarian somatic cells directly affect oocyte growth and function. GDF 9 is expressed in oocytes and is thought to be required for ovarian folliculogenesis.

    Function:
    Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.

    Subunit:
    Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked (By similarity).

    Subcellular Location:
    Secreted (By similarity).

    Tissue Specificity:
    Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level).

    Post-translational modifications:
    Phosphorylated; phosphorylation is critical for GDF9 function. In vitro, can be phosphorylated by CK at Ser-325.

    DISEASE:
    Note=Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins.

    Similarity:
    Belongs to the TGF-beta family.

    SWISS:
    O60383

    Gene ID:
    2661

    Database links:
    Entrez Gene: 2661 Human
    Entrez Gene: 14566 Mouse
    Entrez Gene: 59304 Rat
    Omim: 601918 Human
    SwissProt: O60383 Human
    SwissProt: Q07105 Mouse
    Unigene: 25022 Human
    Unigene: 490461 Mouse
    Unigene: 9714 Mouse
    Unigene: 42874 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    GDF9屬于轉移生長因子–β(TGF-β)及骨形態發生蛋白（BMP）家族成員。