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    首頁>>免疫學>>一抗>>基質金屬蛋白酶-1抗體  
    

    

    
	
    
    	
    
        	
    基質金屬蛋白酶-1抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41906R
      
                        
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      中文名稱：
      
                            
      基質金屬蛋白酶-1抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-MMP-1 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      BN41906R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應：Human,Mouse,Rat,Rabbit(predicted:Dog,Cow,Horse,Sheep)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41906R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse,Rat,Rabbit(predicted:Dog,Cow,Horse,Sheep)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41906R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Mouse,Rat,Rabbit(predicted:Dog,Cow,Horse,Sheep)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱MMP-1
    中文名稱基質金屬蛋白酶-1抗體
    別    名MMP-1; MMP1; CLGN; CLG; collagenase, fibroblast; Fibroblast collagenase; Interstitial collagenase; Matrix metallopeptidase 1 (interstitial collagenase); Matrix metalloprotease 1; Matrix metalloproteinase-1; Matrix Metalloproteinase 1; MMP1_HUMAN; OTTHUMP00000045866;MMP 1.  


    研究領域腫瘤  心血管  細胞生物  信號轉導  細胞骨架  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat, Rabbit,  (predicted: Dog, Cow, Horse, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量27/41/54kDa
    細胞定位細胞外基質 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human MMP-1:251-350/469 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.

    Function:
    Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

    Subunit:
    Interacts with HIV-1 Tat.

    Subcellular Location:
    Secreted, extracellular space, extracellular matrix (Probable).

    Similarity:
    Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.

    SWISS:
    P03956

    Gene ID:
    4312

    Database links:
    Entrez Gene: 4312 Human
    Entrez Gene: 17386 Mouse
    Entrez Gene: 397320 Pig
    Entrez Gene: 100009110 Rabbit
    Omim: 120353 Human
    SwissProt: P28053 Cow
    SwissProt: P03956 Human
    SwissProt: P33435 Mouse
    SwissProt: P21692 Pig
    SwissProt: P13943 Rabbit
    Unigene: 83169 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    基質金屬蛋白酶(matrix metalloproteinases, MMPs)是一族依賴鋅離子而降解各種細胞外基質的蛋白酶，亦稱IV型膠原酶或稱明膠酶A，其主要功能為降解IV型膠原，因而它在腫瘤細胞突破基底膜屏障和浸潤轉移中起重要作用。 目前主要用于各種惡性腫瘤(如乳腺癌、胃腸道癌、卵巢癌、膀胱癌等)中的基底膜檢測與腫瘤轉移浸潤的研究。