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    首頁>>免疫學>>一抗>>促凋亡調節蛋白BNIP3抗體  
    

    

    
	
    
    	
    
        	
    促凋亡調節蛋白BNIP3抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41899R
      
                        
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      中文名稱：
      
                            
      促凋亡調節蛋白BNIP3抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-BNIP3 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      BN41899R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse)   推薦應用：WB,Flow-Cyt,ELISA
      
                            
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      BN41899R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse)   推薦應用：WB,Flow-Cyt,ELISA
      
                            
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      BN41899R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse)   推薦應用：WB,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱BNIP3
    中文名稱促凋亡調節蛋白BNIP3抗體
    別    名BCL2 Adenovirus E1B 19kDa Interacting Protein 3; BCL2/adenovirus E1B 19 kDa protein interacting protein 3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BNIP 3; BNIP3_HUMAN; NIP 3; NIP3.  

    研究領域腫瘤  心血管  免疫學  細胞凋亡  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=2ug/Test 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量22kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human BNIP3:101-194/194 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2.

    Function:
    Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

    Subunit:
    Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains).

    Subcellular Location:
    Mitochondrion. Mitochondrion membrane. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria.

    Similarity:
    Belongs to the NIP3 family.

    SWISS:
    Q12983

    Gene ID:
    664

    Database links:
    Entrez Gene: 664 Human
    Entrez Gene: 12176 Mouse
    Entrez Gene: 84480 Rat
    Omim: 603293 Human
    SwissProt: Q12983 Human
    SwissProt: O55003 Mouse
    Unigene: 144873 Human
    Unigene: 378890 Mouse
    Unigene: 2060 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    BNIP3蛋白在缺氧條件下可誘導細胞發生細胞凋亡。BNIP3促細胞凋亡線粒體途徑根據有無caspase的參與而具有不同的作用機制，也是研究的熱點。BNIP3還可誘導細胞自噬。BNIP3全稱為Bcl2/腺病毒E1B19kD相互作用蛋白3。(Bcl2/adenovirusE1B19kDainteractingprotein3，BNIP3)，是新近發現的BH3only亞家族成員之一，也是低氧敏感的凋亡基因。在化學性低氧誘導細胞凋亡的過程中，ATP是BNIP3導致細胞凋亡的關鍵性因素之一。單獨ATP下降不誘導細胞凋亡，但ATP下降到一定程度能促進BNIP3向線粒體轉位，從而誘導了BNIP3相關的凋亡。這可能是低氧誘導BNIP3表達導致細胞凋亡的重要機制之一。




















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