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    首頁(yè)>>免疫學(xué)>>一抗>>細(xì)胞毒性受體NK-p46抗體  
    

    

    
	
    
    	
    
        	
    細(xì)胞毒性受體NK-p46抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN41809R
      
                        
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      中文名稱：
      
                            
      細(xì)胞毒性受體NK-p46抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-NCR1 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
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      備注
      
                            
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      BN41809R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Human,Mouse   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
      
                            
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      BN41809R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human,Mouse   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
      
                            
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      BN41809R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Human,Mouse   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱NCR1
    中文名稱細(xì)胞毒性受體NK-p46抗體
    別    名Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335; CD 335; LY94; NCTR1_HUMAN.  
    研究領(lǐng)域腫瘤  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse, 
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量31kDa
    細(xì)胞定位細(xì)胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human NCR1:1-100/304 <Extracellular>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.

    Function:
    Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

    Subunit:
    Interacts with CD247 and FCER1G.

    Subcellular Location:
    Cell membrane; Single-pass type I membrane protein.

    Tissue Specificity:
    Selectively expressed by both resting and activated NK cells.

    Similarity:
    Belongs to the natural cytotoxicity receptor (NCR) family.
    Contains 2 Ig-like (immunoglobulin-like) domains.

    SWISS:
    O76036

    Gene ID:
    9437

    Database links:
    Entrez Gene: 9437 Human
    Entrez Gene: 17086 Mouse
    Entrez Gene: 117547 Rat
    Omim: 604530 Human
    SwissProt: O76036 Human
    SwissProt: Q8C567 Mouse
    SwissProt: Q9Z0H5 Rat
    Unigene: 97084 Human
    Unigene: 240231 Mouse
    Unigene: 30049 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    NKp46是很重要的的自然細(xì)胞毒受體，在自然殺傷作用中起關(guān)鍵作用。細(xì)胞毒性受體家族（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表達(dá)于所有靜止和活化的NK細(xì)胞，而NKp44則選擇性的表達(dá)于活化的NK細(xì)胞。靶細(xì)胞上的配體分子與NCRs的結(jié)合（交聯(lián)）引發(fā)NK細(xì)胞的活化導(dǎo)致靶細(xì)胞的裂解和大量細(xì)胞因子的產(chǎn)生。現(xiàn)已確認(rèn)NKp46和NKp44可以識(shí)別病毒上的配體分子紅血球凝聚素，而NKp46則能識(shí)別腫瘤細(xì)胞上的乙酰硫酸多聚糖。