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    首頁>>免疫學(xué)>>一抗>>周斑蛋白抗體  
    

    

    
	
    
    	
    
        	
    周斑蛋白抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號：
      
                            
      BN41800R
      
                        
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      中文名稱：
      
                            
      周斑蛋白抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Periplakin Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價
      
                                
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      BN41800R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Human(predicted:Mouse,Rat)   推薦應(yīng)用：WB
      
                            
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      BN41800R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human(predicted:Mouse,Rat)   推薦應(yīng)用：WB
      
                            
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      BN41800R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Human(predicted:Mouse,Rat)   推薦應(yīng)用：WB
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱Periplakin
    中文名稱周斑蛋白抗體
    別    名190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor; 195 kDa cornified envelope precursor protein; AW553870; KIAA0568; MGC134872; PEPL_HUMAN; Periplakin; ppl.  
    研究領(lǐng)域腫瘤  細胞生物  信號轉(zhuǎn)導(dǎo)  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human,  (predicted: Mouse, Rat, )
    產(chǎn)品應(yīng)用WB=1:500-2000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量205kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Periplakin:1-100/1756 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]

    Function:
    Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.

    Subcellular Location:
    Cell junction > desmosome. Cytoplasm > cytoskeleton. Cell membrane. Nucleus. Mitochondrion. Associated with desmosomes and intermediate filaments.

    Tissue Specificity:
    Expressed in stratified squamous epithelia and in some other epithelia.

    Similarity:
    Belongs to the plakin or cytolinker family.
    Contains 2 plectin repeats.
    Contains 4 spectrin repeats.

    SWISS:
    O60437

    Gene ID:
    5493

    Database links:
    Entrez Gene: 5493 Human
    Entrez Gene: 19041 Mouse
    Entrez Gene: 302934 Rat
    Omim: 602871 Human
    SwissProt: O60437 Human
    SwissProt: Q9R269 Mouse
    Unigene: 192233 Human
    Unigene: 266875 Mouse
    Unigene: 25259 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications