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    首頁(yè)>>免疫學(xué)>>一抗>>VP16 tag抗體  
    

    

    
	
    
    	
    
        	
    VP16 tag抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN41780R
      
                        
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      中文名稱(chēng)：
      
                            
      VP16 tag抗體 
      
                        
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      英文名稱(chēng)：
      
                            
      Rabbit anti-VP16 tag Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價(jià)
      
                                
      備注
      
                            
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      BN41780R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Species independent   推薦應(yīng)用：WB,ELISA
      
                            
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      BN41780R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Species independent   推薦應(yīng)用：WB,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱(chēng)VP16 tag
    中文名稱(chēng)VP16 tag抗體
    別    名VP16_HHV1F;UL48; Tegument protein VP16; Alpha trans-inducing protein; Alpha-TIF; ICP25; Vmw65  
    研究領(lǐng)域免疫學(xué)  細(xì)菌及病毒  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    產(chǎn)品應(yīng)用WB=1:1000-5000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量54kDa
    細(xì)胞定位細(xì)胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from HSV-1 VP16:391-490/490aa 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹HSV evades the immune system through interference with MHC class I antigen presentation on the cell surface, by blocking TAP or the transporter associated with antigen processing induced by the secretion of ICP-47 by HSV. In the host cell, TAP transports digested viral antigen epitope peptides from the cytosol to the endoplasmic reticulum, allowing these epitopes to be combined with MHC class I molecules and presented on the surface of the cell. Viral epitope presentation with MHC class I is a requirement for activation of cytotoxic T-lymphocytes (CTLs), the major effectors of the cell-mediated immune response against virally-infected cells. ICP-47 prevents initiation of a CTL-response against HSV, allowing the virus to survive for a protracted period in the host.

    Function:
    Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection (By similarity).
    May play a role in the aggregation of tegument proteins around nucleocapsids during virus morphogenesis.

    Subunit:
    Interacts with VP22. Interacts with gH (via C-terminus). Interacts with the virion host shutoff protein (vhs). Interacts with VP11/12. Associates with the VP16-induced complex; binding to host HCFC1 activates VP16 for association with the octamer motif-binding host protein POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes (By similarity).

    Similarity:
    Belongs to the herpesviridae tegument protein VP16 protein family.

    SWISS:
    P04486

    Gene ID:
    VP16 tag

    Database links:
    SwissProt: P04486 Human herpesvirus 1


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

















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