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    首頁>>免疫學>>一抗>>凝集素樣氧化型低密度脂蛋白受體抗體  
    

    

    
	
    
    	
    
        	
    凝集素樣氧化型低密度脂蛋白受體抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號：
      
                            
      BN41773R
      
                        
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      中文名稱：
      
                            
      凝集素樣氧化型低密度脂蛋白受體抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-LOX 1 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
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      備注
      
                            
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      BN41773R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應：Human,Rat,Rabbit(predicted:Mouse,Cow)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41773R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Rat,Rabbit(predicted:Mouse,Cow)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41773R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Rat,Rabbit(predicted:Mouse,Cow)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱LOX 1
    中文名稱凝集素樣氧化型低密度脂蛋白受體抗體
    別    名Lectin-type oxidized LDL receptor 1; OLR1; lectin-like low density lipoprotein receptor-1; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; LOX-1; BLOX1; Contains: Oxidized low-density lipoprotein receptor 1, soluble form A; Oxidized low-density lipoprotein receptor 1, soluble form B; OLR1_HUMAN.  


    研究領(lǐng)域心血管  免疫學  信號轉(zhuǎn)導  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Rat, Rabbit,  (predicted: Mouse, Cow, )
    產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量31/50kDa
    細胞定位細胞膜 分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from rabbit LOX-1:201-273/273 <Extracellular>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

    Function:
    Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

    Subunit:
    Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70.

    Subcellular Location:
    Cell membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form also exists.

    Tissue Specificity:
    Highly expressed in endothelial cells, aortic intima and lung. Expressed at low level in other tissues.

    Post-translational modifications:
    N-glycosylated.

    Similarity:
    Contains 1 C-type lectin domain.

    SWISS:
    Q9XTA8

    Gene ID:
    100009322

    Database links:
    Entrez Gene: 4973 Human
    Entrez Gene: 108078 Mouse
    Entrez Gene: 140914 Rat
    Omim: 602601 Human
    SwissProt: P78380 Human
    SwissProt: Q9EQ09 Mouse
    SwissProt: Q9XTA8 Rabbit
    SwissProt: O70156 Rat
    Unigene: 412484 Human
    Unigene: 293626 Mouse
    Unigene: 87449 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    LOX-1(Lectin-like Ox-LDL receptor 1)即氧化低密度脂蛋白的內(nèi)皮受體，是清除受體或稱清道夫受體（Scavenger Receptor,SR）家族的一種，LOX-1作為氧化低密度脂蛋白的天然配體，與脂質(zhì)代謝有關(guān)。