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    首頁(yè)>>免疫學(xué)>>一抗>>腫瘤細(xì)胞調(diào)亡素/死亡受體5抗體  
    

    

    
	
    
    	
    
        	
    腫瘤細(xì)胞調(diào)亡素/死亡受體5抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN41742R
      
                        
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      中文名稱：
      
                            
      腫瘤細(xì)胞調(diào)亡素/死亡受體5抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-DR5 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價(jià)
      
                                
      備注
      
                            
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      BN41742R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Human(predicted:Mouse,Rat)   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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      BN41742R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human(predicted:Mouse,Rat)   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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      BN41742R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Human(predicted:Mouse,Rat)   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱DR5
    中文名稱腫瘤細(xì)胞調(diào)亡素/死亡受體5抗體
    別    名sTRAIL Receptor 2; Death receptor 5; CD 262; CD262; CD262 antigen; Death domain containing receptor for TRAIL/Apo2L; Death receptor 5; DR 5; DR5; Fas like protein precursor; KILLER; KILLER/DR5; p53 regulated DNA damage inducible cell death receptor (killer); TNF related apoptosis inducing ligand receptor 2; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRANCER; TRICK2; TRICK2A; TRICK2B; TRICKB; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor superfamily member 10b; ZTNFR9. 




    研究領(lǐng)域腫瘤  免疫學(xué)  細(xì)胞凋亡  細(xì)胞膜受體  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human,  (predicted: Mouse, Rat, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量48kDa
    細(xì)胞定位細(xì)胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from rat DR5:301-381/381 <Cytoplasmic>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

    Function:
    Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

    Subcellular Location:
    Cell Membrane

    Tissue Specificity:
    Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

    DISEASE:
    Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease may be caused by mutations affecting the gene represented in this entry.

    Similarity:
    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.

    SWISS:
    O14763

    Gene ID:
    364420

    Database links:
    Entrez Gene: 8795 Human
    Entrez Gene: 21933 Mouse
    Entrez Gene: 364420 Rat
    Omim: 603612 Human
    SwissProt: O14763 Human
    SwissProt: Q9QZM4 Mouse
    Unigene: 521456 Human
    Unigene: 193430 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    DR5分布比較廣泛，包括肝、脾、肺、胸腺和活化T細(xì)胞以及一些腫瘤細(xì)胞系。APO-2L在誘導(dǎo)轉(zhuǎn)化細(xì)胞和腫瘤細(xì)胞的調(diào)亡中，廣泛且迅速，多表達(dá)與胞漿。