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    首頁(yè)>>免疫學(xué)>>一抗>>抑制素/腫瘤抑制因子抗體  
    

    

    
	
    
    	
    
        	
    抑制素/腫瘤抑制因子抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN41716R
      
                        
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      中文名稱：
      
                            
      抑制素/腫瘤抑制因子抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Prohibitin Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價(jià)
      
                                
      備注
      
                            
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      BN41716R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Horse)   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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      BN41716R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Horse)   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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      BN41716R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Horse)   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱Prohibitin
    中文名稱阻抑素/腫瘤抑制因子抗體
    別    名Mitochondrial Marker; PHB; PHB1; Prohibitin - Mitochondrial Marker; PHB_HUMAN.  
    研究領(lǐng)域腫瘤  細(xì)胞生物  染色質(zhì)和核信號(hào)  細(xì)胞凋亡  細(xì)胞類型標(biāo)志物  線粒體  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Horse, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量30kDa
    細(xì)胞定位細(xì)胞漿 線粒體
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Prohibitin:171-272/272 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

    Function:
    Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

    Subunit:
    Interacts with PHB2. Interacts with STOML2.

    Subcellular Location:
    Mitochondrion inner membrane.

    Tissue Specificity:
    Widely expressed in different tissues.

    Similarity:
    Belongs to the prohibitin family.

    SWISS:
    P35232

    Gene ID:
    5245

    Database links:
    Entrez Gene: 5245 Human
    Entrez Gene: 18673 Mouse
    Entrez Gene: 25344 Rat
    Omim: 176705 Human
    SwissProt: P35232 Human
    SwissProt: P67778 Mouse
    SwissProt: P67779 Rat
    Unigene: 514303 Human
    Unigene: 263862 Mouse
    Unigene: 29754 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    Prohibitin(phb)基因是一種有效的腫瘤抑制基因，廣泛分布于不同種屬的各種生物細(xì)胞中，它所編碼的產(chǎn)物Prohibitin(PHB)蛋白結(jié)構(gòu)保守，既存在于線粒體內(nèi)膜上，發(fā)揮分子伴侶作用，也存在于細(xì)胞核內(nèi)，具有負(fù)性轉(zhuǎn)錄調(diào)控作用，因而對(duì)細(xì)胞代謝、生長(zhǎng)、分化、衰老以及凋亡等諸多方面發(fā)揮 著重要的調(diào)控作用，可能與某些腫瘤和退行性疾病的發(fā)生有關(guān)。