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轉錄因子家族ETS1抗體

產品貨號：

BN41677R
中文名稱：

轉錄因子家族ETS1抗體
英文名稱：

Rabbit anti-ETS1 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41677R-50ul

50ul

￥1486.00

交叉反應：Human,Mouse,Rat,GuineaPig(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41677R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat,GuineaPig(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41677R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat,GuineaPig(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產品描述

英文名稱	ETS1
中文名稱	轉錄因子家族ETS1抗體
別名	Avian erythroblastosis virus E26 (v ets) oncogene homolog 1; C ets 1 protein; ETS 1; Ets protein; ETS-1; ETS1 protein; ETS1_HUMAN; EWSR 2; EWSR2; FLJ10768; p54; Protein C-ets-1; v ets avian erythroblastosis virus E2 oncogene homolog; v ets avian erythroblastosis virus E26 oncogene homolog 1; v ets erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1.
研究領域	腫瘤免疫學轉錄調節因子
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, G)
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	49kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Ets1:321-441/441
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]. Function: Transcription factor. Subunit: Interacts with MAF and MAFB. Interacts with PAX5, the interaction alters DNA-binding properties. Binds to DAXX. Interacts with UBE2I. Subcellular Location: Nucleus. Post-translational modifications: Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity. Ubiquitinated; which induces proteasomal degradation. Similarity: Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain. SWISS: P14921 Gene ID: 2113 Database links: Entrez Gene: 540313 Cow Entrez Gene: 2113 Human Entrez Gene: 23871 Mouse Entrez Gene: 24356 Rat Omim: 164720 Human SwissProt: P13474 Chicken SwissProt: P15062 Chicken SwissProt: P14921 Human SwissProt: P27577 Mouse SwissProt: P41156 Rat Unigene: 369438 Human Unigene: 292415 Mouse Unigene: 88756 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Ets家族成員在胚胎發生早期的血細胞生成和血管發生及胚胎發育后期的組織發生中發揮重要的調控作用. 成年后Ets在許多組織，如造血組織、血管、腦和中樞神經系統、乳腺、子宮內膜、卵巢、睪丸、腎和肺中均有表達. 由于Ets轉錄因子不同成員在胚胎發育過程中的特異性的表達與其功能關系密切。 Ets家族的重要成員Ets-1的表達與胰腺癌、甲狀腺癌、乳腺癌、胃癌、子宮內膜癌、口腔鱗癌、肝細胞性肝癌(HCC)的發生、轉移有很重要的關系。