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    首頁>>免疫學(xué)>>一抗>>胚胎干細(xì)胞關(guān)鍵蛋白抗體  
    

    

    
	
    
    	
    
        	
    胚胎干細(xì)胞關(guān)鍵蛋白抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號：
      
                            
      BN41655R
      
                        
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      中文名稱：
      
                            
      胚胎干細(xì)胞關(guān)鍵蛋白抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Oct-3/Oct-4 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價(jià)
      
                                
      備注
      
                            
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      BN41655R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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      BN41655R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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      BN41655R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱Oct-3/Oct-4
    中文名稱胚胎干細(xì)胞關(guān)鍵蛋白抗體
    別    名POU domain, class 5, transcription factor 1;Oct-3/4; Oct-4A; Oct4A; Oct 4A; Octamer-binding transcription factor 3; Octamer-4; Octamer-3; Oct-3; NF-A3; Otf-3; Otf3; MGC22487; Oct 3; Oct 4; OCT3; Oct4; Octamer binding protein 3; Octamer binding protein 4; Octamer binding transcription factor 3; Octamer-binding protein 3; Octamer-binding protein 4; OTF 3; OTF 4; OTF-3; OTF3; OTF4; PO5F1_HUMAN; POU class 5 homeobox 1; POU domain class 5 transcription factor 1; POU domain transcription factor OCT4; POU type homeodomain containing DNA binding protein; POU5F1; POU5F1.  



    研究領(lǐng)域細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  干細(xì)胞  表觀遺傳學(xué)  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量39kDa
    細(xì)胞定位細(xì)胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human OCT-4:201-300/360 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Expression of the POU-domain transcription factor Octamer-4 (Oct-4) is widely regarded as a hallmark of pluripotent stem cells. The relationship of Oct-4 to pluripotent stem cells is indicated by its tightly restricted expression to undifferentiated pluripotent stem cells. Upon differentiation to somatic lineages, the expression of Oct-4 disappears rapidly. Unlike the majority of pluripotent stem cell markers, the biological role of Oct-4 has been well characterized. Studies performed in mice point to the critical role of Oct-4 in the establishment and/or maintenance of pluripotent stem cells in an uncommitted state.

    Function:
    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.

    Subunit:
    Interacts with UBE2I and ZSCAN10. Interacts with PKM2. Interacts with WWP2.

    Subcellular Location:
    Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern.

    Tissue Specificity:
    Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.

    Post-translational modifications:
    Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression.
    Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation.
    ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.

    Similarity:
    Belongs to the POU transcription factor family. Class-5 subfamily.
    Contains 1 homeobox DNA-binding domain.
    Contains 1 POU-specific domain.

    SWISS:
    P20263

    Gene ID:
    5460

    Database links:
    Entrez Gene: 5460 Human
    Entrez Gene: 282316 Cow
    Entrez Gene: 18999 Mouse
    Entrez Gene: 100127461 Pig
    Entrez Gene: 294562 Rat
    Omim: 164177 Human
    SwissProt: O97552 Cow
    SwissProt: Q01860 Human
    SwissProt: P20263 Mouse
    SwissProt: Q9TSV5 Pig
    Unigene: 249184 Human
    Unigene: 632482 Human
    Unigene: 646545 Human
    Unigene: 17031 Mouse
    Unigene: 161748 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.