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    首頁>>免疫學(xué)>>一抗>>多藥耐藥相關(guān)蛋白2抗體  
    

    

    
	
    
    	
    
        	
    多藥耐藥相關(guān)蛋白2抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號：
      
                            
      BN41649R
      
                        
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      中文名稱：
      
                            
      多藥耐藥相關(guān)蛋白2抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-MRP2/ABCC2 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
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      備注
      
                            
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      BN41649R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Rat,Mouse,Human   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41649R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Rat,Mouse,Human   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41649R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Rat,Mouse,Human   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱MRP2/ABCC2
    中文名稱多藥耐藥相關(guān)蛋白2抗體
    別    名multidrug resistance-associated protein2; ABC30; ABCC2; ATP binding cassette sub family C (CFTR/MRP) member 2; ATP binding cassette subfamily C member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; CMOAT; CMOAT1; cMRP; DJS; KIAA1010; MRP 2; MRP-2; MRP2; Multidrug resistance associated protein 2; MRP2_HUMAN; ATP-binding cassette sub-family C member 2; Multidrug resistance-associated protein 2.   
    研究領(lǐng)域腫瘤  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse, Rat, 
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量174kDa
    細(xì)胞定位細(xì)胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human MRP2:485-615/1545 <Cytoplasmic>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Belongs to the ABC transporter family.

    Function:
    Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

    Subcellular Location:
    Membrane; Multi-pass membrane protein.

    Tissue Specificity:
    Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.

    DISEASE:
    Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.

    Similarity:
    Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.

    SWISS:
    Q92887

    Gene ID:
    1244

    Database links:
    Entrez Gene: 1244 Human
    Entrez Gene: 12780 Mouse
    Entrez Gene: 25303 Rat
    Omim: 601107 Human
    SwissProt: Q92887 Human
    SwissProt: Q8VI47 Mouse
    SwissProt: Q63120 Rat
    Unigene: 368243 Human
    Unigene: 39054 Mouse
    Unigene: 10265 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    MRP-2作為一種結(jié)合輸出泵，轉(zhuǎn)運(yùn)許多不同的藥物結(jié)合物的蛋白。
    MRP2蛋白的染色陽性產(chǎn)物分布于細(xì)胞漿/膜中。