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    首頁>>免疫學>>一抗>>CD4抗體  
    

    

    
	
    
    	
    
        	
    CD4抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41587R
      
                        
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      中文名稱：
      
                            
      CD4抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-CD4 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      BN41587R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應：Human,Mouse,Rat   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41587R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse,Rat   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41587R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Mouse,Rat   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱CD4
    中文名稱CD4抗體
    別    名CD4 (L3T4); CD4 antigen (p55); CD4 Antigen ; CD4 molecule; CD4 Receptor; CD4+ Lymphocyte deficiency, included; CD4mut; L3T4; Leu3; Ly-4; Lymphocyte antigen CD4; MGC165891; p55; T Cell Antigen T4 ; T cell antigen T4/LEU3; T cell differentiation antigen L3T4; T cell OKT4 deficiency, included; T cell surface antigen T4/Leu 3 ; T cell surface antigen T4/Leu3; T Cell Surface Glycoprotein CD4; W3/25; W3/25 antigen; T-cell surface glycoprotein CD4 isoform 1 precursor; CD4_MOUSE.  



    研究領域細胞生物  免疫學  干細胞  細胞表面分子  淋巴細胞  t-淋巴細胞  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat, 
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3μg/Test IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量48kDa
    細胞定位細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from the middle of mouse CD4:231-330/457 <Extracellular>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010].

    Function:
    Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

    Subunit:
    Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

    Subcellular Location:
    Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

    Post-translational modifications:
    Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.

    Similarity:
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    SWISS:
    P06332

    Gene ID:
    12504

    Database links:
    Entrez Gene: 920 Human
    Entrez Gene: 12504 Mouse
    Omim: 186940 Human
    SwissProt: P06332 Mouse
    SwissProt: P01730 Human
    Unigene: 631659 Human
    Unigene: 2209 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    此抗體可識別55KDⅠ型單鏈穿膜糖蛋白。
    CD4分子是存在于大多數輔助/誘導T細胞表面的59kDa的糖蛋白。正常淋巴組織中CD4的表達數量多于CD8，此抗體主要用于標記輔助/誘導T細胞，與CD8單抗聯合使用對外周血淋巴細胞分型。
    CD4抗原是HLA-II類分子和人類免疫缺陷病毒(HIV)-愛滋病的受體，在35-50%外周血淋巴細胞-輔助和誘導T細胞(Th/Ti)和70-80%人胸腺細胞上表達，在人的單核細胞表面也有低密度的表達。
    CD4抗原有膜結合型和可溶性兩種形式。Th/Ti可輔助Ig產生和T細胞毒T細胞的作用。