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    首頁(yè)>>免疫學(xué)>>一抗>>白細(xì)胞介素10抗體  
    

    

    
	
    
    	
    
        	
    白細(xì)胞介素10抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN41576R
      
                        
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      中文名稱：
      
                            
      白細(xì)胞介素10抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-IL-10 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
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      備注
      
                            
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      BN41576R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41576R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41576R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱IL-10
    中文名稱白細(xì)胞介素10抗體
    別    名Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. 

    研究領(lǐng)域細(xì)胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse,  (predicted: Rat, Chicken, Pig, Rabbit, Sheep, Guinea Pig, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量18kDa
    細(xì)胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human IL-10:101-178/178 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹IL-10 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

    Function:
    Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

    Subunit:
    Homodimer.

    Subcellular Location:
    Secreted.

    Tissue Specificity:
    Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.

    Similarity:
    Belongs to the IL-10 family.

    SWISS:
    P18893

    Gene ID:
    3586

    Database links:
    Entrez Gene: 3586 Human
    Entrez Gene: 16153 Mouse
    Entrez Gene: 25325 Rat
    Omim: 124092 Human
    SwissProt: P22301 Human
    SwissProt: P18893 Mouse
    SwissProt: P29456 Rat
    Unigene: 193717 Human
    Unigene: 874 Mouse
    Unigene: 9868 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    白細(xì)胞介素-10(IL-10)是主要由Th2細(xì)胞所產(chǎn)生的一種細(xì)胞因子，活化的B細(xì)胞、單核巨噬細(xì)胞和枯否氏細(xì)胞（Kupffer's cell）等也可產(chǎn)生IL-10。它是以抑制Th細(xì)胞克隆細(xì)胞因子合成為特點(diǎn)的多效免疫調(diào)節(jié)因子。
    白介素-10是維護(hù)細(xì)胞因子網(wǎng)絡(luò)平衡的重要負(fù)調(diào)節(jié)因子。其作用機(jī)制可能是降低抗原遞呈細(xì)胞MHCⅡ類抗原表達(dá)，或誘導(dǎo)抗原遞呈細(xì)胞產(chǎn)生另一種細(xì)胞因子，改變細(xì)胞內(nèi)信號(hào)傳遞途徑，從而選擇性抑制某些細(xì)胞因子mRNA轉(zhuǎn)錄，并與Th2細(xì)胞產(chǎn)生的IL-4、IL-5有協(xié)同作用。