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    最近搜索：細胞培養 微生物學 分子生物 生物化學 
    

    

    
	
    首頁>>免疫學>>一抗>>高遷移率族蛋白B1抗體  
    

    

    
	
    
    	
    
        	
    高遷移率族蛋白B1抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41571R
      
                        
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      中文名稱：
      
                            
      高遷移率族蛋白B1抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-HMGB1 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      BN41571R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應：Rat,Mouse,Human(predicted:Cow)   推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
      
                            
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      BN41571R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Rat,Mouse,Human(predicted:Cow)   推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
      
                            
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      BN41571R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Rat,Mouse,Human(predicted:Cow)   推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱HMGB1
    中文名稱高遷移率族蛋白B1抗體
    別    名Amphoterin; High mobility group 1; High Mobility Group Box 1; High mobility group protein 1; High mobility group protein B1; HMG3; HMGB 1;HMGB-1; Hmgb1 protein; Nonhistone chromosomal protein HMG1; SBP 1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; HMGB1_HUMAN.  


    研究領域腫瘤  細胞生物  免疫學  轉錄調節因子  結合蛋白  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Cow, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量25kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human HMGB1:75-170/215 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, a vagus nerve dependent mechanism, inhibits HMGB1 release in experimental disease models

    Function:
    DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.

    Subunit:
    Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2.

    Subcellular Location:
    Nucleus. Chromosome.

    Similarity:
    Belongs to the HMGB family.
    Contains 2 HMG box DNA-binding domains.

    SWISS:
    P09429

    Gene ID:
    3146

    Database links:
    Entrez Gene: 282691 Cow
    Entrez Gene: 3146 Human
    Entrez Gene: 100862258 Mouse
    Entrez Gene: 15289 Mouse
    Entrez Gene: 25459 Rat
    Omim: 163905 Human
    SwissProt: P10103 Cow
    SwissProt: P09429 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    近來的研究表明稱之為高遷移率族蛋白B-1（HMG-B1）的核內結構蛋白在核外表達時是一種有效的早期炎癥介質。
    高遷移性Ｂ１組蛋白（ＨＭＧＢ１）： 是一種核結合蛋白，在ＤＮＡ重組、修復、復制和基因轉錄中起作用。ＨＭＧＢ１也是巨噬細胞分泌的一種介質。
    此外，高遷移性Ｂ１組蛋白亦被受刺激的巨噬細胞或單核細胞主動分泌。在這一主動分泌過程中，HMGB1首先經乙酰化并由核內轉移至溶酶體內，繼而在ATP和溶血磷脂膽堿兩種分泌信號指導下轉移至細胞外。由壞死細胞被動釋放的HMGB1和炎癥細胞主動分泌的HMGB1存在分子上的差異。胞外的HMGB1可作為細胞因子參與信號傳導，因為它既可識別Toll 樣受體（TLR）家族的一些成員，又能與識別晚期糖基化終末產物受體（RAGE）相作用。
    HMGB1能啟動炎癥反應，包括產生多種細胞因子、對某些干細胞產生趨化作用、誘導血管粘附分子、削弱腸上皮細胞的功能等。