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    首頁(yè)>>免疫學(xué)>>一抗>>鈣/鈣調(diào)素依賴蛋白激酶2α抗體  
    

    

    
	
    
    	
    
        	
    鈣/鈣調(diào)素依賴蛋白激酶2α抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN41553R
      
                        
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      中文名稱：
      
                            
      鈣/鈣調(diào)素依賴蛋白激酶2α抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-CaMK2 alpha Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
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      備注
      
                            
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      BN41553R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,GuineaPig)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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      BN41553R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,GuineaPig)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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      BN41553R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,GuineaPig)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱CaMK2 alpha
    中文名稱鈣/鈣調(diào)素依賴蛋白激酶2α抗體
    別    名alpha CaMKII; CaMKII alpha; Calcium / Calmodulin Dependent Protein Kinase II G; Calcium calmodulin dependent protein kinase CaM kinase II alpha; Calcium calmodulin dependent protein kinase II alpha-B subunit; Calcium calmodulin dependent protein kinase II; Calcium/calmodulin dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; Calcium/calmodulin-dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase II-alpha; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type IIA; CaM kinase II alpha chain; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CAM2; CaMK II alpha subunit; CaMK-II subunit alpha; CAMK2A; CAMKA; CAMKB; CaMKII; CaMK 2a; CaMK2a; KCC2A_HUMAN.  
    研究領(lǐng)域激酶和磷酸酶  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Guinea Pig, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量54kDa
    細(xì)胞定位細(xì)胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human CaMK2a:401-478/478 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008].

    Function:
    CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.

    Subunit:
    CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.

    Subcellular Location:
    Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse. Note=Postsynaptic lipid rafts.

    Similarity:
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Contains 1 protein kinase domain.

    SWISS:
    Q9UQM7

    Gene ID:
    815

    Database links:
    Entrez Gene: 815 Human
    Entrez Gene: 12322 Mouse
    Entrez Gene: 25400 Rat
    Omim: 114078 Human
    SwissProt: Q9UQM7 Human
    SwissProt: P11798 Mouse
    SwissProt: P11275 Rat
    Unigene: 725992 Human
    Unigene: 131530 Mouse
    Unigene: 107499 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    CaMK2a也是絲/蘇氨基酸激酶的一種，同屬于Ca++/鈣調(diào)素依賴性蛋白質(zhì)激酶家族成員。