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    首頁>>免疫學>>一抗>>凋亡調節基因之一抗體  
    

    

    
	
    
    	
    
        	
    凋亡調節基因之一抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41491R
      
                        
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      中文名稱：
      
                            
      凋亡調節基因之一抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-FLIP Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN41491R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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      BN41491R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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      BN41491R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱FLIP
    中文名稱凋亡調節基因之一抗體
    別    名CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p43; Flice-like Inhibitory protein; c FLIP; c FLIPL; c FLIPR; c FLIPS; c-FLIP; CASH; CASP8 and FADD like apoptosis regulator; CASP8 and FADD like apoptosis regulator precursor; CASP8AP1; Caspase Eight Related Protein; Caspase homolog; Caspase Homologue; Caspase Like Apoptosis Regulatory Protein; Caspase related inducer of apoptosis; CASPER; Cellular FLICE like inhibitory protein; CFLA; CFLAR; CLARP; FADD like anti apoptotic molecule; FADD Like Anti-apoptotic Molecule 1; FADD-like antiapoptotic molecule 1; FADD like antiapoptotic molecule 1; FADD Like Apoptosis Regulator; FLAME 1; FLAME; FLAME1; FLAME-1; FLICE Inhibitor Protein; FLIP; FLIPs; I FLICE; I-FLICE; Inhibitor of FLICE; Inhibitor of FLICE; MACH Related Inducer of Toxicity; MACH-related inducer of toxicity; mFLIP; MRIT; USURPIN; Usurpin beta; FLICE-like inhibitory protein short form; FLICE-like inhibitory protein long form; CFLAR_HUMAN; Cellular FLICE-like inhibitory protein.  
    研究領域腫瘤  細胞生物  信號轉導  細胞凋亡  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Rabbit, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量43/52kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human CASP8 and FADD-like apoptosis regulator subunit p43:7-100/480 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

    Function:
    Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

    Subunit:
    TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.

    Tissue Specificity:
    Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.

    Post-translational modifications:
    Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.

    Similarity:
    Belongs to the peptidase C14A family.
    Contains 2 DED (death effector) domains.

    SWISS:
    O15519

    Gene ID:
    8837

    Database links:
    Entrez Gene: 8837 Human
    Entrez Gene: 12633 Mouse
    Entrez Gene: 117279 Rat
    Omim: 603599 Human
    SwissProt: O15519 Human
    SwissProt: O35732 Mouse
    Unigene: 390736 Human
    Unigene: 336848 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    FLIP參與凋亡的調節。此抗體在長型和短型的FLIP異構體中均表達。短型FLIP包含2個死亡效應基因結構區，同源于FAS相關蛋白死亡效應基因結構區。長型FLIP包含1個附加的Caspase 樣結構區，但是他缺少一個催化部位和在大多數Caspase 蛋白中形成底物結合束的殘基。

















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