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    首頁>>免疫學>>一抗>>血紅蛋白β抗體  
    

    

    
	
    
    	
    
        	
    血紅蛋白β抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41337R
      
                        
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      中文名稱：
      
                            
      血紅蛋白β抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Hemoglobin Beta Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      備注
      
                            
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      BN41337R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human   推薦應用：WB,ELISA
      
                            
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      BN41337R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human   推薦應用：WB,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱Hemoglobin Beta
    中文名稱血紅蛋白β抗體
    別    名Beta 1 globin; beta globin; beta globin chain; BETA GLOBIN TYPE; BETA THALASSEMIAS; CD113t C; CD113t-C; ERYTHREMIA; HBB; Hemoglobin beta 1 chain; hemoglobin beta chain; hemoglobin beta chain complex; Hemoglobin beta chain, major form; HEMOGLOBIN BETA LOCUS; METHEMOGLOBINEMIA  
    研究領域心血管  細胞生物  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, 
    產品應用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量15.5kDa
    細胞定位細胞漿 分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Hemoglobin beta:51-147/147 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008].

    Function:
    Involved in oxygen transport from the lung to the various peripheral tissues.

    Tissue Specificity:
    Red blood cells.

    Post-translational modifications:
    The initiator Met is not cleaved in variant Thionville and is acetylated.

    DISEASE:
    Defects in HBA1/HBA2 may be a cause of Heinz body anemias (HEIBAN) [MIM:140700]. This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability.
    Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency.


    Similarity:
    Belongs to the globin family.

    SWISS:
    P68871

    Gene ID:
    3043

    Database links:
    Entrez Gene: 3043 Human
    Omim: 141900 Human
    SwissProt: P68871 Human
    Unigene: 523443 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.