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    首頁>>免疫學>>一抗>>磷酸化二氫嘧啶酶樣2抗體  
    

    

    
	
    
    	
    
        	
    磷酸化二氫嘧啶酶樣2抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41315R
      
                        
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      中文名稱：
      
                            
      磷酸化二氫嘧啶酶樣2抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Phospho-CRMP2 (Thr514+Ser518) Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
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      BN41315R-100ul
      
                                
      100ul
      
                                
      ￥2470.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Chicken,Pig,Cow,Horse,Sheep)   推薦應用：IHC-P,IHC-F,IF
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱Phospho-CRMP2 (Thr514+Ser518)
    中文名稱磷酸化二氫嘧啶酶樣2(CRMP2/DPYL2)抗體
    別    名CRMP2 (phospho T514 + S518); CRMP2 (phospho T514+S518); CRMP-2(phospho Thr514+S518); p-CRMP2(Thr514+S518); CRMP2/Dpysl2(DRP 2; Collapsin response mediator protein 2; Collapsin response mediator protein hCRMP 2; CRAM; CRMP 2; DHPRP 2; DHPRP2; Dihydr pyrimidinase 2; Dihydropyrimidinase 2; Dihydropyrimidinase like 2; Dihydropyrimidinase like 2 long form;Dihydropyrimidinase related protein 2; DPYL 2; DPYL2; DPYSL 2; DPYSL2; DRP 2; DRP2; Musunc 33; Musunc33; N2A3; TOAD 64; TOAD64; ULIP 2 protein; Ulip2.  
    產品類型磷酸化抗體 
    研究領域細胞生物  免疫學  神經生物學  生長因子和激素  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Chicken, Pig, Cow, Horse, Sheep, )
    產品應用IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量62kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthesised phosphopeptide derived from human CRMP2 around the phosphorylation site of Thr514+Ser518:TV(p-T)PAS(p-S)AK 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease.

    Function:
    Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.

    Subunit:
    Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4 (By similarity). Interacts with CLN6.

    Subcellular Location:
    Cytoplasm.

    Tissue Specificity:
    Ubiquitous.

    Post-translational modifications:
    3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
    Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.

    Similarity:
    Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

    SWISS:
    Q16555

    Gene ID:
    1808

    Database links:
    Entrez Gene: 1808 Human
    Entrez Gene: 12934 Mouse
    Entrez Gene: 25416 Rat
    Omim: 602463 Human
    SwissProt: Q16555 Human
    SwissProt: O08553 Mouse
    SwissProt: P47942 Rat
    Unigene: 173381 Human
    Unigene: 593187 Human
    Unigene: 352648 Mouse
    Unigene: 475100 Mouse
    Unigene: 2889 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications