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    首頁>>免疫學>>一抗>>巢蛋白/神經上皮干細胞蛋白抗體  
    

    

    
	
    
    	
    
        	
    巢蛋白/神經上皮干細胞蛋白抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41309R
      
                        
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      中文名稱：
      
                            
      巢蛋白/神經上皮干細胞蛋白抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Nestin Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN41309R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human(predicted:Cow)   推薦應用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
      
                            
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      BN41309R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human(predicted:Cow)   推薦應用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱Nestin
    中文名稱巢蛋白/神經上皮干細胞蛋白抗體
    別    名ESTM 46; FLJ 21841; FLJ21841; Intermediate filament protein; Nbla00170; Nes; NEST_RAT; Nestin.  
    研究領域細胞生物  發育生物學  神經生物學  干細胞  細胞類型標志物  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Cow, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量177kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Nestin:21-120/1621 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Nestin is a Class VI intermediate filament expressed in the developing central nervous system (CNS) in early embryonic neuroepithelial stem cells. This protein has been widely used as a predominant marker for stem / progenitor cells, glioma cells, and tumor endothelial cells in the mammalian CNS. Furthermore, it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumor.

    Function:
    Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.

    Subunit:
    Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, this protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3.

    Subcellular Location:
    Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3

    Tissue Specificity:
    CNS stem cells.

    Post-translational modifications:
    Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized.

    Similarity:
    Belongs to the intermediate filament family.

    SWISS:
    P48681

    Gene ID:
    10763

    Database links:

    Entrez Gene: 10763 Human
    Entrez Gene: 18008 Mouse
    Entrez Gene: 25491 Rat
    Omim: 600915 Human
    SwissProt: P48681 Human
    SwissProt: Q6P5H2 Mouse
    SwissProt: P21263 Rat
    Unigene: 527971 Human
    Unigene: 331129 Mouse
    Unigene: 9701 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


    神經干細胞標志物
    在動物體早期發育過程中，中樞神經系統發育尤為重要 。Nestin是一種中等纖維蛋白，它在哺乳動物神經前體細胞中表達較高，目前已被廣泛用于神經前體細胞的重要標志分子。研究Nestin的表達調控規律，將有助于人們認識神經前體細胞的生物特性。此抗體還表達中樞神經系統干細胞及神經上皮細胞。