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    首頁>>免疫學>>一抗>>細胞分裂周期蛋白2抗體  
    

    

    
	
    
    	
    
        	
    細胞分裂周期蛋白2抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41274R
      
                        
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      中文名稱：
      
                            
      細胞分裂周期蛋白2抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-CDCA2 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN41274R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41274R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱CDCA2
    中文名稱細胞分裂周期蛋白2抗體
    別    名cell division cycle associated 2; Recruits PP1 onto mitotic chromatin at anaphase protein; Repo Man; Repo-Man; CDCA2_HUMAN.  
    研究領域細胞生物  細胞周期蛋白  細胞分化  表觀遺傳學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse,  (predicted: Rat, Dog, Pig, Horse, Rabbit, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量113kDa
    細胞定位細胞核 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human CDCA2:361-450/1023 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹CDCA2 is a regulator of chromosome structure during mitosis. CDCA2 forms an essential complex with protein phosphatase PP1-gamma subunit 1 (PPP1CC) and is required for the recruitment of PP1 to chromatin. Knockdown of CDCA2 by RNAi causes large-scale cell death by apoptosis, as does overexpression of a dominant-negative mutant of the protein.

    Function:
    Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.

    Subunit:
    Interacts with PPP1CC.

    Subcellular Location:
    Nucleus. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin. [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q69YH5-1; Sequence=Displayed; Name=2; IsoId=Q69YH5-2; Sequence=VSP_025598, VSP_025599; Note=No experimental confirmation available.

    Tissue Specificity:
    Ubiquitously expressed.

    Post-translational modifications:
    Phosphorylated by CDK1. May regulate its subcellular location.

    SWISS:
    Q69YH5

    Gene ID:
    157313

    Database links:
    Entrez Gene: 157313 Human
    SwissProt: Q69YH5 Human
    Unigene: 33366 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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