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    首頁>>免疫學>>一抗>>錨定蛋白B抗體  
    

    

    
	
    
    	
    
        	
    錨定蛋白B抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41239R
      
                        
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      中文名稱：
      
                            
      錨定蛋白B抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Ankyrin B Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
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      BN41239R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Mouse(predicted:Human,Rat,Pig,Cow,Horse)   推薦應用：IHC-P,ELISA
      
                            
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      BN41239R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Mouse(predicted:Human,Rat,Pig,Cow,Horse)   推薦應用：IHC-P,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱Ankyrin B
    中文名稱錨定蛋白B抗體
    別    名ANK-2; Ank2; ANK2_HUMAN; Ankyrin 2; Ankyrin 2 brain; Ankyrin B; Ankyrin nonerythroid; ANKYRIN, NEURONAL; Ankyrin-2; Ankyrin-B; Brain ankyrin; Non-erythroid ankyrin  
    研究領域免疫學  神經生物學  信號轉導  細胞粘附分子  細胞骨架  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量426kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Ankyrin B:1901-2100/3957 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Members of the Ankyrin family of proteins mediate the attachment of integral membrane proteins to the cytoskeleton. ANK1, ANK2 and ANK3 genes encode for the proteins in this family, Ankyrin-1 (also designated Ankyrin R), Ankyrin B and Ankyrin G, respectively. The proteins are structured similarly each composed of an N-terminal domain with multiple ankyrin repeats, a highly conserved central spectrin binding domain, and C-terminal regulatory domains which are susceptible to the most variance. Both Ankyrin B and Ankyrin G are essential for normal neuronal functions. Ankyrin B, or brain Ankyrin is predominantly expressed in the plasma membrane of neurons as well as glial cells throughout the brain. Two transcripts have been described with alternative splicing resulting in additional isoforms. The Ankyrin B protein associates with the spectrin-actin network, mediates axon fasciculation, and stabilizes axon bundles. Ankyrin B is required for coordinated assembly of Na/Ca exchanger, Na/K ATPase, and inositol trisphosphate (InsP(3)) receptor at transverse-tubule/sarcoplasmic reticulum sites in cardiomyocytes.

    Function:
    Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate.

    Subunit:
    Interacts with RHBG and SPTBN1.

    Subcellular Location:
    Cytoplasm, cytoskeleton. Membrane. Cytoplasm, myofibril, sarcomere, M line. Apical cell membrane. Cell membrane.

    Tissue Specificity:
    Present in plasma membrane of neurons as well as glial cells throughout the brain. Expressed in fetal brain and in temporal cortex of adult brain. Also expressed in the inner segments of rod photoreceptors in retina.

    DISEASE:
    Defects in ANK2 are the cause of long QT syndrome type 4 (LQT4) [MIM:600919]; also known as sick sinus syndrome with bradycardia. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. LQT4 displays many atypical features compared to classical long QT syndromes, including pronounced sinus bradycardia, polyphasic T waves and atrial fibrillation. Cardiac repolarization defects may be not as severe as in classical LQT syndromes and prolonged QT interval on EKG is not a consistent feature.

    Similarity:
    Contains 24 ANK repeats.
    Contains 2 death domains.
    Contains 2 ZU5 domains.

    SWISS:
    Q01484

    Gene ID:
    287

    Database links:



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.