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    首頁>>免疫學>>一抗>>雙微體2癌基因結合蛋白抗體  
    

    

    
	
    
    	
    
        	
    雙微體2癌基因結合蛋白抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41213R
      
                        
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      中文名稱：
      
                            
      雙微體2癌基因結合蛋白抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-MDM2BP Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN41213R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Sheep)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41213R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Sheep)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱MDM2BP
    中文名稱雙微體2癌基因結合蛋白抗體
    別    名MDM 2 binding protein; MDM 2 BP; MDM2 (mouse double minute 2) binding protein 104kD; MDM2 (mouse double minute 2) binding protein; MDM2 binding protein; MDM2 BP; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein; MDM2BP; Mouse double minute 2 homolog binding protein; MTBP_HUMAN.  
    研究領域腫瘤  細胞生物  染色質和核信號  細胞周期蛋白  表觀遺傳學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量102kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human MTBP/MDM2BP:821-904/904 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation.

    Function:
    Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.

    Subunit:
    Interacts with MDM2.

    Similarity:
    Belongs to the MTBP family.

    SWISS:
    Q96DY7

    Gene ID:
    27085

    Database links:
    Entrez Gene: 27085 Human
    Entrez Gene: 105837 Mouse
    Omim: 605927 Human
    SwissProt: Q96DY7 Human
    SwissProt: Q80VU3 Mouse
    SwissProt: Q8BJS8 Mouse
    SwissProt: Q8BTU9 Mouse
    SwissProt: Q8BTW0 Mouse
    SwissProt: Q9ER61 Mouse
    Unigene: 186433 Human
    Unigene: 46701 Human
    Unigene: 61901 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.