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    首頁(yè)>>免疫學(xué)>>一抗>>絲氨酸/蘇氨酸蛋白激酶38抗體  
    

    

    
	
    
    	
    
        	
    絲氨酸/蘇氨酸蛋白激酶38抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN41205R
      
                        
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      中文名稱：
      
                            
      絲氨酸/蘇氨酸蛋白激酶38抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-STK38 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價(jià)
      
                                
      備注
      
                            
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      BN41205R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,GuineaPig)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41205R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,GuineaPig)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱STK38
    中文名稱絲氨酸/蘇氨酸蛋白激酶38抗體
    別    名NDR 1; NDR1; NDR1 protein kinase; Nuclear Dbf2 related kinase 1; Serine/threonine protein kinase 38; STK 38; STK-38; STK38_HUMAN.  
    研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Guinea Pig, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量51kDa
    細(xì)胞定位細(xì)胞核 細(xì)胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human STK38:31-130/465 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹STK38 belongs to the NDR family of serine/threonine protein kinases. NDR kinases require the phosphorylation of conserved Ser/Thr residues for activation. NDR family members have two unique stretches of primary sequence: an N-terminal regulatory (NTR) domain and an insert of several residues between subdomains VII and VIII of the kinase domain. The kinase domain insert functions as an auto-inhibitory sequence (AIS), while binding of the co-activator MOB (Mps-one binder) proteins to the NTR domain releases NDR kinases from inhibition of autophosphorylation. STK38 negatively regulates the activation of MEKK1/2 by direct interaction with the catalytic domain of MEKK1/2. The negative regulation of MEKK1/2 is not due to its phosphorylation by STK38.

    Function:
    Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2.

    Subunit:
    Homodimeric S100B binds two molecules of STK38.

    Subcellular Location:
    Nucleus. Cytoplasm.

    Tissue Specificity:
    Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.

    Post-translational modifications:
    ISGylated (Probable).
    Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B.

    Similarity:
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain.

    SWISS:
    Q15208

    Gene ID:
    11329

    Database links:
    Entrez Gene: 11329 Human
    Entrez Gene: 106504 Mouse
    Omim: 606964 Human
    SwissProt: Q15208 Human
    SwissProt: Q91VJ4 Mouse
    Unigene: 409578 Human
    Unigene: 439986 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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