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    首頁>>免疫學>>一抗>>絲氨酸蛋白酶8抗體  
    

    

    
	
    
    	
    
        	
    絲氨酸蛋白酶8抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41190R
      
                        
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      中文名稱：
      
                            
      絲氨酸蛋白酶8抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-PRSS8 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      備注
      
                            
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      BN41190R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41190R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱PRSS8
    中文名稱絲氨酸蛋白酶8抗體
    別    名CAP1; Channel Activating Protease 1; mCAP1; Prostasin; Prostasin heavy chain; protease, serine, 8; Prss8; PRSS8_HUMAN; Serine protease 8.  
    研究領域腫瘤  細胞生物  激酶和磷酸酶  腫瘤細胞生物標志物  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量30/33kDa
    細胞定位細胞膜 細胞外基質 分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human PRSS8:65-165/343 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹PRSS8 is a member of the trypsin family of serine proteases. It can be found in seminal fluid and is highly expressed in prostate epithelia. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. The carboxyterminal region contains a GPI anchor sequence, which anchors prostasin to the cell surface. Phospholipase activity is thought to liberate prostasin from the cell, and cleavage of the linker region also releases prostasin. PRSS8 has been proposed as a marker for ovarian cancer, where it is up-regulated, a marker for androgen-refractory prostate cancer, where it is down-regulated, and as an inhibitor of invasiveness in breast cancer.

    Function:
    Possesses a trypsin-like cleavage specificity.

    Subunit:
    Heterodimer of two chains, light and heavy, held by a disulfide bond.

    Subcellular Location:
    Prostasin: Cell membrane; Single-pass membrane protein. Prostasin light chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus. Prostasin heavy chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.

    Tissue Specificity:
    Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid.

    Similarity:
    Belongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.

    SWISS:
    Q16651

    Gene ID:
    5652

    Database links:
    Entrez Gene: 5652 Human
    Entrez Gene: 76560 Mouse
    Entrez Gene: 192107 Rat
    Omim: 600823 Human
    SwissProt: Q16651 Human
    SwissProt: Q9ESD1 Mouse
    SwissProt: Q9ES87 Rat
    Unigene: 75799 Human
    Unigene: 5875 Mouse
    Unigene: 107364 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.