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    首頁>>免疫學>>一抗>>MAS1癌基因抗體  
    

    

    
	
    
    	
    
        	
    MAS1癌基因抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41178R
      
                        
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      中文名稱：
      
                            
      MAS1癌基因抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-MAS1 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN41178R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig)   推薦應用：IHC-P,Flow-Cyt,ELISA
      
                            
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      BN41178R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig)   推薦應用：IHC-P,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱MAS1
    中文名稱MAS1癌基因抗體
    別    名Mas-related G protein-coupled receptor A; MAS1 oncogene; MAS; MGRA; MAS_HUMAN.  

    研究領域腫瘤  免疫學  信號轉導  生長因子和激素  細胞周期蛋白  轉錄調節因子  細胞表面分子  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1ug/Test （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量37kDa
    細胞定位細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human MAS1:51-150/325 <Extracellular>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP binding proteins and share a conserved structural motif, which is described as a '7 transmembrane segment' following the prediction that these hydrophobic segments form membrane spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth regulating pathway to bring about oncogenic effects.

    Function:
    Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

    Subunit:
    Interacts with AGTR1 (Probable).

    Subcellular Location:
    Cell membrane; Multi-pass membrane protein.

    Similarity:
    Belongs to the G-protein coupled receptor 1 family.

    SWISS:
    P04201

    Gene ID:
    4142

    Database links:
    Entrez Gene: 4142 Human
    Omim: 165180 Human
    SwissProt: P04201 Human
    Unigene: 99900 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.












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