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    首頁>>免疫學>>一抗>>磷酸化成骨特異性轉錄因子抗體  
    

    

    
	
    
    	
    
        	
    磷酸化成骨特異性轉錄因子抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41160R
      
                        
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      中文名稱：
      
                            
      磷酸化成骨特異性轉錄因子抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-phospho-RUNX2 (Ser451) Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      BN41160R-100ul
      
                                
      100ul
      
                                
      ￥2470.00
      
                                
      交叉反應：Human(predicted:Chicken,Dog,Pig,Cow,Horse)   推薦應用：Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱phospho-RUNX2 (Ser451)
    中文名稱磷酸化成骨特異性轉錄因子抗體
    別    名RUNX2(phospho S451); Runt-related Transcription Factor 2; CBF alpha 1; CBFA1; CCD; CCD1; Cleidocranial dysplasia 1; Core binding factor; Core binding factor runt domain alpha subunit 1; Core binding factor subunit alpha 1; MGC120023; Oncogene AML 3; OSF 2; OSF2; Osteoblast specific transcription factor 2; OTTHUMP00000016533; PEA2 alpha A; PEA2aA; PEBP2 alpha A; PEBP2A1; PEBP2A2; PEBP2aA1; Polyomavirus enhancer binding protein 2 alpha A subunit; Runt domain; Runt related transcription factor 2; SL3 3 enhancer factor 1 alpha A subunit; SL3/AKV core binding factor alpha A subunit.  



    產品類型磷酸化抗體 
    研究領域免疫學  干細胞  轉錄調節因子  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Chicken, Dog, Pig, Cow, Horse, )
    產品應用ELISA=1:5000-10000 Flow-Cyt=1ug/Test 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量67kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human RUNX2 around the phosphorylation site of Ser451:TS(p-S)GS 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation.

    Subunit:
    Heterodimer of an alpha and a beta subunit. Interacts with HIVEP3 (By similarity). The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with G22P1 (Ku70) and XRCC5 (Ku80). Interacts with MYST3 and MYST4.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Specifically expressed in osteoblasts.

    Similarity:
    Contains 1 Runt domain.

    SWISS:
    Q13950

    Gene ID:
    860

    Database links:
    Entrez Gene: 860 Human
    Entrez Gene: 12393 Mouse
    Entrez Gene: 100155806 Pig
    Entrez Gene: 367218 Rat
    Omim: 600211 Human
    SwissProt: Q13950 Human
    SwissProt: Q9XSB7 Horse
    SwissProt: Q08775 Mouse
    SwissProt: Q9Z2J9 Rat
    Unigene: 535845 Human
    Unigene: 391013 Mouse
    Unigene: 391017 Mouse
    Unigene: 214214 Rat
    Unigene: 83672 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    RUNX2又稱：Cbfα1(Core-binding factor, alpha 3 subunit) 是新發現的一類調控間充質干細胞向成骨方向分化的特異性轉錄因子,參與骨形成,骨骼生長和發育的一類重要細胞,它起源于多能間充質干細胞,是間













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