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    首頁>>免疫學>>一抗>>早老素γ分泌酶抗體  
    

    

    
	
    
    	
    
        	
    早老素γ分泌酶抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41007R
      
                        
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      中文名稱：
      
                            
      早老素γ分泌酶抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-APH1a Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      備注
      
                            
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      BN41007R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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      BN41007R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱APH1a
    中文名稱早老素γ分泌酶抗體
    別    名Anterior Pharynx Defective 1; Anterior pharynx defective 1 homolog A; APH 1A; Aph 1alpha; APH-1a; Aph-1alpha; Aph1a; APH1A_HUMAN; CGI 78; CGI78; Gamma secretase subunit APH 1A; Gamma Secretase Subunit APH1a; Gamma-secretase subunit APH-1A; Likely ortholog of C. elegans anterior pharynx defective 1A; Presenilin Stabilization Factor; Presenilin-stabilization factor; PSF; UNQ579/PRO1141.  
    研究領域免疫學  神經生物學  干細胞  Alzheimer's  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量30kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human APH1a:71-170/265 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹APH1a is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the APH-1 family.

    Function:
    Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

    Subcellular Location:
    Endoplasmic reticulum membrane.

    Tissue Specificity:
    Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.

    Similarity:
    Belongs to the APH-1 family.

    SWISS:
    Q96BI3

    Gene ID:
    51107

    Database links:
    Entrez Gene: 539247 Cow
    Entrez Gene: 483181 Dog
    Entrez Gene: 51107 Human
    Entrez Gene: 226548 Mouse
    Entrez Gene: 365872 Rat
    Omim: 607629 Human
    SwissProt: Q96BI3 Human
    SwissProt: Q8BVF7 Mouse
    Unigene: 108408 Human
    Unigene: 306954 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications











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