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    首頁(yè)>>免疫學(xué)>>一抗>>P21蛋白激活的蛋白激酶6抗體  
    

    

    
	
    
    	
    
        	
    P21蛋白激活的蛋白激酶6抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN40999R
      
                        
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      中文名稱：
      
                            
      P21蛋白激活的蛋白激酶6抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-PAK6 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價(jià)
      
                                
      備注
      
                            
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      BN40999R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit)   推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
      
                            
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      BN40999R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit)   推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱PAK6
    中文名稱P21蛋白激活的蛋白激酶6抗體
    別    名CDKN1A activated kinase 6; Serine/threonine-protein kinase PAK 6; p21 activated protein kinase 6; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A) activated kinase 6; p21-ACTIVATED KINASE 6; p21activated kinase 6; PAK 5; PAK 6; PAK5; Serine threonine protein kinase PAK 6; Serine/threonine protein kinase PAK 6; Serine/threonine protein kinase PAK6; EC 2.7.1.37; PAK-5; PAK-6; Pak6; PAK6_HUMAN.  
    研究領(lǐng)域腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
    產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量75kDa
    細(xì)胞定位細(xì)胞核 細(xì)胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human PAK6:511-610/681 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.

    Function:
    Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.

    Subunit:
    Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.

    Subcellular Location:
    Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.

    Tissue Specificity:
    Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.

    Post-translational modifications:
    Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.

    Similarity:
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 CRIB domain.
    Contains 1 protein kinase domain.

    SWISS:
    Q9NQU5

    Gene ID:
    56924

    Database links:
    Entrez Gene: 56924 Human
    Omim: 608110 Human
    SwissProt: Q9NQU5 Human
    Unigene: 513645 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.























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