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BN40937R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,ELISA
BN40937R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,ELISA
產(chǎn)品描述
| 英文名稱(chēng) | PPIG |
| 中文名稱(chēng) | 親環(huán)蛋白（親環(huán)素）PPIG抗體 |
| 別 名 | CARS cyclophilin; CARS Cyp; CARS-cyclophilin; CARS-Cyp; CASP 10; CASP10; Clk associating RS cyclophilin; Clk-associating RS-cyclophilin; Cyclophilin G; CyclophilinG; CYP; MGC133241; Peptidyl prolyl cis trans isomerase G; Peptidyl prolyl isomerase G; Peptidyl-prolyl cis-trans isomerase G; Peptidyl-prolyl isomerase G; Peptidylprolyl isomerase G (cyclophilin G); Peptidylprolyl isomerase G; PPIase G; Ppig; PPIG_HUMAN; Rotamase G; RotamaseG; SCAF10; SR cyclophilin; SR cyp; SR related CTD associated factor 10; SR-cyclophilin; SR-cyp; SRcyp. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 89kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PPIG:351-450/754 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | PPIG belongs to the the peptidyl-prolyl cis/trans isomerase protein family (PPIases). PPIases accelerate the folding of proteins. PPIG catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and is implicated in the folding, transport, and assembly of proteins. It is distributed in nuclear speckles, a nuclear compartment rich in splicing factors, and colocalizes with the splicing factors SC35 and pinin, suggesting a role in the regulation of pre-mRNA splicing. Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. Subunit: Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II. Subcellular Location: Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 PPIase cyclophilin-type domain. SWISS: Q13427 Gene ID: 9360 Database links: Entrez Gene: 9360 Human Entrez Gene: 228005 Mouse Omim: 606093 Human SwissProt: Q13427 Human SwissProt: A2AR02 Mouse Unigene: 727580 Human Unigene: 11815 Mouse Unigene: 474951 Mouse Unigene: 10898 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肽基脯氨酰基順?lè)串悩?gòu)酶，廣泛存在于各種組織和器官。根據(jù)對(duì)免疫抑制劑的敏感性，分屬三個(gè)獨(dú)立的家族：親環(huán)蛋白PPIG、FK506結(jié)合蛋白和細(xì)蛋白。能夠加速自身折疊和體內(nèi)新生肽鏈折疊及變性蛋白質(zhì)的體外折疊，主要分布于內(nèi)質(zhì)網(wǎng)。 |
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