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    首頁>>免疫學(xué)>>一抗>>磷酸化親環(huán)蛋白（親環(huán)素）PPIG抗體  
    

    

    
	
    
    	
    
        	
    磷酸化親環(huán)蛋白（親環(huán)素）PPIG抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號：
      
                            
      BN40925R
      
                        
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      中文名稱：
      
                            
      磷酸化親環(huán)蛋白（親環(huán)素）PPIG抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Phospho-PPIG (Ser376) Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
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      備注
      
                            
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      BN40925R-100ul
      
                                
      100ul
      
                                
      ￥2470.00
      
                                
      交叉反應(yīng)：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Sheep)   推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱Phospho-PPIG (Ser376)
    中文名稱磷酸化親環(huán)蛋白（親環(huán)素）PPIG抗體
    別    名CARS cyclophilin; CARS Cyp; CASP 10; CASP10; Clk associating RS cyclophilin; Cyclophilin G; CyclophilinG; CYP; MGC133241; Peptidyl prolyl cis trans isomerase G; Peptidyl prolyl isomerase G; Peptidylprolyl isomerase G (cyclophilin G); Peptidylprolyl isomerase G; PPIase G; Rotamase G; RotamaseG; PPIG_HUMAN.  
    產(chǎn)品類型磷酸化抗體 
    研究領(lǐng)域細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量89kDa
    細(xì)胞定位細(xì)胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human PPIG around the phosphorylation site of Ser376:VS(p-S)GE 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹PPIG belongs to the the peptidyl-prolyl cis/trans isomerase protein family (PPIases). PPIases accelerate the folding of proteins. PPIG catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and is implicated in the folding, transport, and assembly of proteins. It is distributed in nuclear speckles, a nuclear compartment rich in splicing factors, and colocalizes with the splicing factors SC35 and pinin, suggesting a role in the regulation of pre-mRNA splicing.

    Function:
    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.

    Subunit:
    Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II.

    Subcellular Location:
    Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles.

    Tissue Specificity:
    Ubiquitous.

    Post-translational modifications:
    Phosphorylated upon DNA damage, probably by ATM or ATR.

    Similarity:
    Contains 1 PPIase cyclophilin-type domain.

    SWISS:
    Q13427

    Gene ID:
    9360

    Database links:
    Entrez Gene: 9360 Human
    Entrez Gene: 228005 Mouse
    Entrez Gene: 83624 Rat
    Omim: 606093 Human
    SwissProt: Q13427 Human
    SwissProt: A2AR02 Mouse
    SwissProt: O55035 Rat
    Unigene: 727580 Human
    Unigene: 11815 Mouse
    Unigene: 474951 Mouse
    Unigene: 10898 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    肽基脯氨酰基順反異構(gòu)酶，廣泛存在于各種組織和器官。根據(jù)對免疫抑制劑的敏感性，分屬三個(gè)獨(dú)立的家族：親環(huán)蛋白PPIG、FK506結(jié)合蛋白和細(xì)蛋白。能夠加速自身折疊和體內(nèi)新生肽鏈折疊及變性蛋白質(zhì)的體外折疊，主要分布于內(nèi)質(zhì)網(wǎng)。

















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