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    首頁>>免疫學>>一抗>>磷酸化蛋白激酶樣內質網激酶抗體  
    

    

    
	
    
    	
    
        	
    磷酸化蛋白激酶樣內質網激酶抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40896R
      
                        
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      中文名稱：
      
                            
      磷酸化蛋白激酶樣內質網激酶抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Phospho-PERK (Thr980) Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN40896R-100ul
      
                                
      100ul
      
                                
      ￥2470.00
      
                                
      交叉反應：Rat,Mouse,Human(predicted:Rabbit,Cow,Pig,Dog)   推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱Phospho-PERK (Thr980)
    中文名稱磷酸化蛋白激酶樣內質網激酶抗體
    別    名p-PERK(Thr980); PERK(Phospho Thr980); PERK(Phospho T980); HRI; HsPEK; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; WRS; DKFZp781H1925; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2 alpha kinase 3; Heme regulated EIF2 alpha kinase.  

    產品類型磷酸化抗體 
    研究領域腫瘤  免疫學  信號轉導  細胞凋亡  轉錄調節因子  激酶和磷酸酶  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Rabbit, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量119kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthesised phosphopeptide derived from mouse PERK around the phosphorylation site of Thr980:H(p-T)GQ 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010].

    Function:
    Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.

    Subunit:
    Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3.

    Subcellular Location:
    Endoplasmic reticulum membrane; Single-pass type I membrane protein.

    Tissue Specificity:
    Ubiquitous.

    Post-translational modifications:
    Autophosphorylated.
    N-glycosylated.

    Similarity:
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
    Contains 1 protein kinase domain.

    SWISS:
    Q9Z2B5

    Gene ID:
    13666

    Database links:
    Entrez Gene: 9451 Human
    Entrez Gene: 13666 Mouse
    Entrez Gene: 29702 Rat
    Omim: 604032 Human
    SwissProt: Q9NZJ5 Human
    SwissProt: Q9Z2B5 Mouse
    SwissProt: Q9Z1Z1 Rat
    Unigene: 591589 Human
    Unigene: 247167 Mouse
    Unigene: 24897 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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