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    首頁>>免疫學>>一抗>>磷酸化周期素E1抗體  
    

    

    
	
    
    	
    
        	
    磷酸化周期素E1抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40863R
      
                        
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      中文名稱：
      
                            
      磷酸化周期素E1抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-phospho-Cyclin E1 (Thr77) Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      BN40863R-100ul
      
                                
      100ul
      
                                
      ￥2470.00
      
                                
      交叉反應：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit)   推薦應用：WB,Flow-Cyt,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱phospho-Cyclin E1 (Thr77)
    中文名稱磷酸化周期素E1抗體
    別    名Cyclin E1 (phospho-Thr77); Cyclin E1 (phospho-T77); CCNE 1; CCNE; CCNE1; Cyclin Es; Cyclin Et; CyclinE; G1/S specific cyclin E; G1/S-specific cyclin-E1; CCNE1_HUMAN; pCCNE1.  
    產品類型磷酸化抗體 
    研究領域腫瘤  細胞生物  細胞周期蛋白  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg /Test 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量47kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human Cyclin E around the phosphorylation site of Thr77:IP(p-T)PD 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

    Function:
    Essential for the control of the cell cycle at the G1/S (start) transition.

    Subunit:
    Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.

    Post-translational modifications:
    Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.
    Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.

    Similarity:
    Belongs to the cyclin family. Cyclin E subfamily.

    SWISS:
    P24864

    Gene ID:
    898

    Database links:
    Entrez Gene: 898 Human
    Entrez Gene: 12447 Mouse
    Entrez Gene: 25729 Rat
    Omim: 123837 Human
    SwissProt: P24864 Human
    SwissProt: Q61457 Mouse
    SwissProt: P39949 Rat
    Unigene: 244723 Human
    Unigene: 16110 Mouse
    Unigene: 15455 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

        細胞周期素E是調控細胞G-1→S期轉變的關鍵因素。由于在多種腫瘤中的不適當表達,細胞周期素E現在已明確為原癌基因。