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    首頁>>免疫學>>一抗>>瞬時受體電位離子通道蛋白/M亞家族抗體  
    

    

    
	
    
    	
    
        	
    瞬時受體電位離子通道蛋白/M亞家族抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40835R
      
                        
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      中文名稱：
      
                            
      瞬時受體電位離子通道蛋白/M亞家族抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-TRPM2 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN40835R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human(predicted:Mouse,Rat,Horse)   推薦應用：ELISA
      
                            
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      BN40835R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human(predicted:Mouse,Rat,Horse)   推薦應用：ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱TRPM2
    中文名稱瞬時受體電位離子通道蛋白/M亞家族抗體
    別    名EREG 1; EREG1; TRPM2_HUMAN; Estrogen responsive element associated gene 1; Estrogen responsive element associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTRPC2; NUDT9H; NUDT9L1; putative Ca2+ channel protein; transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; TRPC 7; TRPC7.  
    研究領域免疫學  神經生物學  通道蛋白  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Mouse, Rat, Horse, )
    產品應用WB=1:500-2000 ELISA=1:2000-5000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量165kDa
    細胞定位細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human TRPM2:951-1050/1503 <Extracellular>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹TRPM2 is a Ca(2+)-permeable channel that is activated by oxidative stress and confers susceptibility to cell death.

    Subunit:
    Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death.

    Subcellular Location:
    Membrane; Multi-pass membrane protein.

    Tissue Specificity:
    Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.

    Similarity:
    Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
    Contains 1 nudix hydrolase domain.

    SWISS:
    O94759

    Gene ID:
    7226

    Database links:
    Entrez Gene: 7226 Human
    Entrez Gene: 28240 Mouse
    Entrez Gene: 294329 Rat
    Omim: 603749 Human
    SwissProt: O94759 Human
    SwissProt: Q5KTC0 Mouse
    SwissProt: Q91YD4 Mouse
    SwissProt: Q5G856 Rat
    Unigene: 369759 Human
    Unigene: 276762 Mouse
    Unigene: 214495 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    TRPM2 屬于瞬時受體電位離子通道蛋白家族的M亞家族，是一種非選擇性的陽離子通道蛋白, 是離子通道蛋白參與了單核細胞的氧化應激應答反應，與老年性癡呆等神經退行疾病的發生與發展有著十分密切的聯系.












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