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    首頁>>免疫學>>一抗>>組蛋白去乙酰化酶6抗體  
    

    

    
	
    
    	
    
        	
    組蛋白去乙酰化酶6抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40834R
      
                        
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      中文名稱：
      
                            
      組蛋白去乙酰化酶6抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-HDAC6 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      產品規(guī)格
      
                                
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      BN40834R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Rat(predicted:Mouse,Cow,Horse,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN40834R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Rat(predicted:Mouse,Cow,Horse,Rabbit)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱HDAC6
    中文名稱組蛋白去乙酰化酶6抗體
    別    名HD 6; HD6; HDAC 6; Histone deacetylase 6; HD6; Histone deacetylase 6; JM 21; JM21; KIAA0901; FLJ16239; HDAC6_HUMAN.  
    研究領域腫瘤  發(fā)育生物學  信號轉導  細胞凋亡  轉錄調節(jié)因子  表觀遺傳學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Rat,  (predicted: Mouse, Cow, Horse, Rabbit, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量134kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human HDAC6:301-400/1215 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008].

    Function:
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
    In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

    Subunit:
    Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15 (By similarity). Interacts with DDIT3/CHOP.

    Subcellular Location:
    Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules.

    Post-translational modifications:
    Phosphorylated by AURKA.
    Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
    Sumoylated in vitro.

    Similarity:
    Belongs to the histone deacetylase family. HD type 2 subfamily.
    Contains 1 UBP-type zinc finger.

    SWISS:
    Q9UBN7

    Gene ID:
    10013

    Database links:
    Entrez Gene: 10013 Human
    Entrez Gene: 15185 Mouse
    Entrez Gene: 84581 Rat
    Omim: 300272 Human
    SwissProt: Q9UBN7 Human
    SwissProt: Q9Z2V5 Mouse
    Unigene: 6764 Human
    Unigene: 29854 Mouse
    Unigene: 13453 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

     組蛋白去乙酰化酶(HDACs)是一組在細胞染色質水平、通過誘導組蛋白去乙酰化來調控包括染色質重組、轉錄活化或抑制、細胞周期、細胞分化及細胞凋亡等一系列生物學效應的酶，特別是與細胞活化后的基因轉錄表達調控有關。
        HDAC6是一種比較獨特的組蛋白去乙酰化酶，含有兩個功能上相互獨立的HDAC催化結構域。HDAC6可以去乙酰化組蛋白并抑制相關基因轉錄。
        HDAC6可以和微管(microtuble)結合，可以去乙酰化tubulin，Hsp90和cortactin等。目前發(fā)現大量的蛋白可以被乙酰化修飾，因此HDAC等乙酰化修飾酶被認為在基因轉錄調控、信號轉導、生長發(fā)育、分化凋亡、代謝性疾病和腫瘤等多種生理病理過程中發(fā)揮重要作用。HDAC的抑制劑目前被認為是很有前景的腫瘤治療藥物。
        內源性HDAC6主要定位于細胞漿，與微管相結合并且是一個微管蛋白去乙酰化酶。HDAC6含有一個鋅指結構域，該結構域可能和泛素化降解的調節(jié)有關。HDAC6可以和DHAC11相互作用。