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    首頁>>免疫學>>一抗>>沉默調節相關蛋白2抗體  
    

    

    
	
    
    	
    
        	
    沉默調節相關蛋白2抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40810R
      
                        
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      中文名稱：
      
                            
      沉默調節相關蛋白2抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-SIRT2 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      BN40810R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep)   推薦應用：WB,IHC-P
      
                            
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      BN40810R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep)   推薦應用：WB,IHC-P
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱SIRT2
    中文名稱沉默調節相關蛋白2抗體
    別    名FLJ35621; FLJ37491; NAD dependent deacetylase sirtuin 2; NAD-dependent deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; Silencing information regulator 2 like; Silent information regulator 2; Silent mating type information regulation 2; Silent mating type information regulation 2 homolog; SIR 2; SIR2; SIR2 like; SIR2 like protein 2; Sir2 related protein type 2; SIR2-like protein 2; SIR2L; SIR2L2; SIRT 2; SIRT2; SIRT2_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae); Sirtuin 2; Sirtuin type 2; Sirtuin2.  
    研究領域細胞生物  信號轉導  細胞周期蛋白  轉錄調節因子  表觀遺傳學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
    產品應用WB=1:500-2000 IHC-P=1:400-800 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量26kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human SIRT2:261-360/389 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

    Function:
    NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.

    Subcellular Location:
    Cytoplasm, cytoskeleton. Colocalizes with microtubules.

    Tissue Specificity:
    Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.

    Post-translational modifications:
    Phosphorylated at the G2/M transition of the cell cycle.

    Similarity:
    Belongs to the sirtuin family.
    Contains 1 deacetylase sirtuin-type domain.

    SWISS:
    Q8IXJ6

    Gene ID:
    22933

    Database links:
    Entrez Gene: 22933 Human
    Omim: 604480 Human
    SwissProt: Q8IXJ6 Human
    Unigene: 466693 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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