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    首頁>>免疫學>>一抗>>β-酪蛋白抗體  
    

    

    
	
    
    	
    
        	
    β-酪蛋白抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40793R
      
                        
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      中文名稱：
      
                            
      β-酪蛋白抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Beta casein Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      備注
      
                            
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      BN40793R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Cow,Goat   推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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      BN40793R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Cow,Goat   推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱Beta casein
    中文名稱β-酪蛋白抗體
    別    名Beta-casein; CASB; CASB_SHEEP; Casein beta; CSN 2; Csn2.   
    研究領域細胞生物  免疫學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Cow, Goat, 
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量24kDa
    細胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Beta casein:1-100/226 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. b- and k-caseins are the only caseins present in human milk. The b-casein/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human b-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of b-casein. A common set of transcription factors are required for the expression of b-casein. Multiple binding sites for Stat5, C/EBPb (CCAAT/enchancer-binding protein) and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the b-casein gene. b-casein gene transcription is regulated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insulin and hydrocortisone in mammary epithelial cells. NFkB functions as a negative regulator of b-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation

    Function:
    Important role in determination of the surface properties of the casein micelles. Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide. Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A. Antioxidant peptide has antioxidant activity.

    Subcellular Location:
    Secreted.

    Tissue Specificity:
    Mammary gland specific. Secreted in milk.

    Similarity:
    Belongs to the beta-casein family.

    SWISS:
    P11839

    Gene ID:
    443391

    Database links:
    Entrez Gene: 1447 Human
    Entrez Gene: 281099 Bovin
    Entrez Gene: 443391 Sheep
    Omim: 115460 Human
    SwissProt: P05814 Human
    SwissProt: P02666 Bovin
    Unigene: 2242 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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