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    首頁>>免疫學(xué)>>一抗>>胚胎干細(xì)胞關(guān)鍵蛋白抗體  
    

    

    
	
    
    	
    
        	
    胚胎干細(xì)胞關(guān)鍵蛋白抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號：
      
                            
      BN40762R
      
                        
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      中文名稱：
      
                            
      胚胎干細(xì)胞關(guān)鍵蛋白抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-SOX2 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價(jià)
      
                                
      備注
      
                            
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      BN40762R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Rat,Mouse(predicted:Sheep,Horse,Cow,Dog,Chicken,Human)   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF
      
                            
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      BN40762R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Rat,Mouse(predicted:Sheep,Horse,Cow,Dog,Chicken,Human)   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱SOX2
    中文名稱胚胎干細(xì)胞關(guān)鍵蛋白抗體
    別    名transcriptional factor SOX2; ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MGC148683; MGC2413; RGD1565646; Sex determining region Y box 2; Sex determining region Y-box 2; SOX 2; SRY (sex determining region Y) box 2; SRY box containing gene 2; SRY related HMG box 2; SRY related HMG box gene 2; SRY-box 2; ysb; SOX2_HUMAN; Transcription factor SOX-2; SOX2_HUMAN.  
    研究領(lǐng)域腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  干細(xì)胞  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Horse, Sheep, )
    產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量34kDa
    細(xì)胞定位細(xì)胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human SOX2:1-100/317 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008].

    Function:
    Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.

    Subunit:
    Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.

    Subcellular Location:
    Nucleus.

    Post-translational modifications:
    Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.

    DISEASE:
    Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.

    Similarity:
    Contains 1 HMG box DNA-binding domain.

    SWISS:
    P48431

    Gene ID:
    6657

    Database links:
    Entrez Gene: 6657 Human
    Entrez Gene: 20674 Mouse
    Omim: 184429 Human
    SwissProt: P48431 Human
    SwissProt: P48432 Mouse
    Unigene: 518438 Human
    Unigene: 65396 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    Embryonic Stem Cell Marker (胚胎干細(xì)胞標(biāo)志物)
    轉(zhuǎn)錄因子:胚胎干細(xì)胞相關(guān)蛋白Sox2是sox基因家族的一個(gè)成員,Sox2與Oct4、Nanog一樣是胚胎干細(xì)胞重要的轉(zhuǎn)錄因子，是維持干細(xì)胞特性中起到重要的作用因子；由于它在早期胚胎發(fā)生、神經(jīng)分化和晶狀體發(fā)育等多種重要的發(fā)育事件中都起著關(guān)鍵的作用,從而引起了越來越廣泛的關(guān)注。