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    首頁>>免疫學>>一抗>>環(huán)指蛋白105抗體  
    

    

    
	
    
    	
    
        	
    環(huán)指蛋白105抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號：
      
                            
      BN40695R
      
                        
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      中文名稱：
      
                            
      環(huán)指蛋白105抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-RNF105 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
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      備注
      
                            
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      BN40695R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Mouse,Rat(predicted:Human)   推薦應用：IHC-P
      
                            
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      BN40695R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Mouse,Rat(predicted:Human)   推薦應用：IHC-P
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱RNF105
    中文名稱環(huán)指蛋白105抗體
    別    名DCRR1; E3 ubiquitin protein ligase TTC3; E3 ubiquitin-protein ligase TTC3; Protein DCRR1; RING finger protein 105;Tetratricopeptide repeat protein 3 (TPR repeat protein D); Tetratricopeptide repeat protein 3; TPR repeat protein 3; TPR repeat protein D; TPRD; TPRDI; TPRDII; TPRDIII; TTC3; TTC3_HUMAN.  
    研究領(lǐng)域細胞生物  神經(jīng)生物學  信號轉(zhuǎn)導  G蛋白信號  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, )
    產(chǎn)品應用IHC-P=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量230kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human RNF105:251-350/2025 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.

    Function:
    E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.

    Subunit:
    Interacts (when phosphorylated on Ser-378) with AKT1, AKT2 and AKT3 (when phosphorylated). Interacts with CIT.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Found in all tissues examined.

    Post-translational modifications:
    Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.

    Similarity:
    Contains 1 RING-type zinc finger.
    Contains 4 TPR repeats.

    SWISS:
    P53804

    Gene ID:
    7267

    Database links:
    Entrez Gene: 7267 Human
    Omim: 602259 Human
    SwissProt: P53804 Human
    Unigene: 368214 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.