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    首頁>>免疫學(xué)>>一抗>>半乳糖凝集素3抗體
    半乳糖凝集素3抗體
    • 產(chǎn)品貨號(hào):
      BN40632R
    • 中文名稱:
      半乳糖凝集素3抗體
    • 英文名稱:
      Rabbit anti-Galectin 3 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號(hào)

      產(chǎn)品規(guī)格

      售價(jià)

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    • BN40632R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Human,Mouse(predicted:Rat,Dog) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN40632R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Human,Mouse(predicted:Rat,Dog) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱Galectin 3
    中文名稱半乳糖凝集素3抗體
    別    名Galectin-3; 35 kDa lectin; Carbohydrate binding protein 35; CBP 35; CBP35; GAL 3; GAL3; GAL-3; Galactose specific lectin 3; Galactose-specific lectin 3; Galactoside binding protein; Galactoside-binding protein; GALBP; Galectin3 internal gene,included; Galectin-3; Galectin3; GALIG; GBP; IgE binding protein; IgE-binding protein; L 31; L 34; L-34 galactoside-binding lectin; L31; Laminin binding protein; Laminin-binding protein; Lectin galactose binding soluble 3; Lectin galactoside binding soluble 3; Lectin L 29; Lectin L-29; Lectin, galactose binding, soluble 3; LGALS 3; LGALS2; LGALS3; LGALS3 protein; MAC 2 antigen; Mac-2; MAC2; Macrophage galactose-specific lectin; MGC105387;Galectin- 3; LEG3_HUMAN.  





    研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  細(xì)胞粘附分子  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test ICC=1:100 IF=1:100-500 (石蠟切片需做抗原修復(fù))
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量29kDa
    細(xì)胞定位細(xì)胞核 細(xì)胞漿 分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Galectin 3:181-250/250 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].

    Function:
    Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

    Subunit:
    Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.

    Subcellular Location:
    Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface.

    Tissue Specificity:
    A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages.

    Similarity:
    Contains 1 galectin domain.

    SWISS:
    P17931

    Gene ID:
    3958

    Database links:

    Entrez Gene: 3958 Human

    Entrez Gene: 16854 Mouse

    Entrez Gene: 83781 Rat

    Omim: 153619 Human

    SwissProt: P17931 Human

    SwissProt: P16110 Mouse

    SwissProt: P08699 Rat

    Unigene: 531081 Human

    Unigene: 248615 Mouse

    Unigene: 764 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    Galectin-3是Galectin(半乳凝素)家族的一員,能識(shí)別糖蛋白和糖脂的特異性低聚糖結(jié)構(gòu),參與多種生理和病理過程,包括細(xì)胞生長和凋亡、細(xì)胞黏附、新生血管形成和腫瘤浸潤與轉(zhuǎn)移等。Galectin-3在腫瘤的發(fā)生、發(fā)展及轉(zhuǎn)移中起重要作用。
    Galectin-3在某些腫瘤組織中高表達(dá),其在不同類型腫瘤,如結(jié)直腸癌、胃癌、胰腺癌、甲狀腺癌及肺癌等患者中的高表達(dá)水平,與低生存、腫瘤復(fù)發(fā)、預(yù)后差及對(duì)化療藥物敏感性降低相關(guān)對(duì)于某些腫瘤,Galectin-3有可能成為一個(gè)有價(jià)值的診斷標(biāo)志和治療靶點(diǎn)。