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    首頁>>免疫學>>一抗>>核突觸蛋白-β抗體  
    

    

    
	
    
    	
    
        	
    核突觸蛋白-β抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40629R
      
                        
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      中文名稱：
      
                            
      核突觸蛋白-β抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-beta-Synuclein  Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      備注
      
                            
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      BN40629R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Mouse,Rat(predicted:Human,Cow,Rabbit,Sheep)   推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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      BN40629R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Mouse,Rat(predicted:Human,Cow,Rabbit,Sheep)   推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱beta-Synuclein
    中文名稱核突觸蛋白-β抗體
    別    名14 kDa brain-specific protein; Beta-synuclein; Phosphoneuroprotein 14; PNP14; Sncb; Synuclein beta; SYUB_HUMAN;   
    研究領域細胞生物  神經生物學  信號轉導  細胞凋亡  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, Cow, Rabbit, Sheep, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量14kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human beta-Synuclein :51-100/140 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

    Function:
    Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

    Subcellular Location:
    Cytoplasm

    Tissue Specificity:
    Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

    Post-translational modifications:
    Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.

    Similarity:
    Belongs to the synuclein family.

    SWISS:
    Q16143

    Gene ID:
    6620

    Database links:
    Entrez Gene: 6620 Human
    Entrez Gene: 104069 Mouse
    Entrez Gene: 113893 Rat
    Omim: 602569 Human
    SwissProt: Q16143 Human
    SwissProt: Q91ZZ3 Mouse
    SwissProt: Q63754 Rat
    Unigene: 90297 Human
    Unigene: 200843 Mouse
    Unigene: 20352 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.