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    首頁>>免疫學>>一抗>>甘氨酸受體β/GlyR β抗體  
    

    

    
	
    
    	
    
        	
    甘氨酸受體β/GlyR β抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN40601R
      
                        
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      中文名稱：
      
                            
      甘氨酸受體β/GlyR β抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-GLRB Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產品規格
      
                                
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      備注
      
                            
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      BN40601R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep)   推薦應用：WB,IHC-P,IHC-F,ICC,IF
      
                            
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      BN40601R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep)   推薦應用：WB,IHC-P,IHC-F,ICC,IF
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱GLRB
    中文名稱甘氨酸受體β/GlyR β抗體
    別    名Glycine receptor 58 kDa subunit; Glycine receptor beta; Glycine receptor subunit beta; Glycine receptor, beta subunit; GLRB_HUMAN.  
    研究領域細胞生物  神經生物學  信號轉導  通道蛋白  細胞膜受體  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
    產品應用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量54kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human GLRB:51-150/497 <Extracellular>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹GLRB (Glycine receptor beta) is a neurotransmitter-gated ion channel concentrated within the spinal cord and brainstem. Expression is also observed in several upper brain regions including the cortex, cerebellum, hippocampus and amygdala. Binding of glycine to GLRB increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing), controlling spinal reflexes and locomotor behavior.

    Function:
    The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).

    Subunit:
    Pentamer composed of alpha and beta subunits. Interacts with GPHN

    Subcellular Location:
    Plasma membrane; multi-pass membrane protein.

    DISEASE:
    Defects in GLRB are the cause of hyperekplexia type 2 (HKPX2) [MIM:614619]. HKPX2 is a neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile2 stimuli.

    Similarity:
    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub-subfamily.

    SWISS:
    P48167

    Gene ID:
    2743

    Database links:
    Entrez Gene: 2743 Human
    Entrez Gene: 14658 Mouse
    Entrez Gene: 25456 Rat
    Omim: 138492 Human
    SwissProt: P48167 Human
    SwissProt: P48168 Mouse
    SwissProt: P20781 Rat
    Unigene: 32973 Human
    Unigene: 275639 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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