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    首頁>>免疫學>>一抗>>激肽釋放酶9抗體（舒血管素9）  
    

    

    
	
    
    	
    
        	
    激肽釋放酶9抗體（舒血管素9）
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號：
      
                            
      BN40571R
      
                        
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      中文名稱：
      
                            
      激肽釋放酶9抗體（舒血管素9） 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-KLK9 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
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      備注
      
                            
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      BN40571R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Mouse(predicted:Human,Rat,Horse)   推薦應用：IHC-P,IHC-F,IF,ELISA
      
                            
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      BN40571R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Mouse(predicted:Human,Rat,Horse)   推薦應用：IHC-P,IHC-F,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱KLK9
    中文名稱激肽釋放酶9抗體（舒血管素9）
    別    名Kallikrein 8; Kallikrein 9; Kallikrein L3; Kallikrein Like 3; Kallikrein like protein 3; kallikrein related peptidase 9; Kallikrein-9; Kallikrein-like protein 3; Kallikrein8; Kallikrein9; KLK 8; KLK 9; KLK L3; KLK-L3; KLK8; KLK9; KLK9_HUMAN; KLKL 3; KLKL3.  
    研究領域腫瘤  細胞生物  信號轉(zhuǎn)導  激酶和磷酸酶  細胞骨架  細胞外基質(zhì)  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse,  (predicted: Human, Rat, Horse, )
    產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量26kDa
    細胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human KLK9:51-150/250 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Kallikrein 9, also known as Kallikrein-Like 3 (KLK-L3), is a chymotrypsin-like serine proteinase. Kallikrein 9 was discovered as the locus for kallikreins on chromosome 19 was more fully mapped and found by similarity to the other tissue kallikreins. Kallikrein 9 has been found in the ovary, thymus, testis, prostate, skin, breast and neuronal tissues and is made by many cell lines in culture. Kallikrein 9 levels in breast cancer and uterine cancer patients have been reported to drop as the disease progresses, thus hK9 might be considered a favorable prognostic marker. Different splice variants of hK9 have been reported, although it is not yet known if they produce functional proteins. The full length Kallikrein 9 encodes for a 250 amino acid protein, with a predicted mass of 27.5 kDa and a pI of 7.53. The 234 amino acid form predicts a protein of 26 kDa with a pI of 9.76 and this quite basic pI might give the shorter form a very different function or localization. The shorter sequence also diverges before the catalytic serine residue, making it unlikely to be proteolytically active. Pre-pro-kallikrein 9 has the 17 amino acid signal sequence is removed before secretion, and the Pro-kallikrein 9 is activated to Kallikrein 9 by removal of the 5 amino acid propeptide domain.

    Subcellular Location:
    Secreted (Probable).

    Tissue Specificity:
    Skin, thymus, trachea, cerebellum and spinal cord.

    Similarity:
    Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.

    SWISS:
    Q9UKQ9

    Gene ID:
    284366

    Database links:
    Entrez Gene: 284366 Human
    Omim: 605504 Human
    SwissProt: Q9UKQ9 Human
    Unigene: 448942 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    KLK9目前認為是卵巢癌 宮頸癌 子宮內(nèi)膜癌等其他腫瘤,很有意義的標志物。激肽釋放酶KLK是激肽系統(tǒng)的主要限速酶，它是一組存在于多數(shù)組織和體液中的絲氨酸蛋白酶，是一種肽鏈內(nèi)切酶。KLK又稱血管舒緩素，包括15個家族成員。在不同的組織中廣泛表達,具有蛋白水解酶的活性。它特異性的在碳末端切割底物肽，可裂解激肽原釋放具有活性的激肽，由激肽發(fā)揮對心血管系統(tǒng)及腎臟功能的調(diào)節(jié)作用。
    組織KLK是一個大的基因家族，主要分布在肺、腎、血管、腦、腎上腺組織，為一種中等大小的糖蛋白。
















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